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中华眼科医学杂志(电子版) ›› 2020, Vol. 10 ›› Issue (04) : 193 -197. doi: 10.3877/cma.j.issn.2095-2007.2020.04.001

所属专题： 青少年近视防控；

述评

重视儿童眼底病的规范筛查、诊断和治疗
卢海1,†(), 刘敬花1, 焦永红1, 佘海澄1   
  1. 1. 100730　首都医科大学附属北京同仁医院　北京同仁眼科中心　北京市眼科研究所　北京市眼视光与视觉科学重点实验室
  • 收稿日期:2020-07-20 出版日期:2020-08-28
  • 通信作者: 卢海
  • 基金资助:
    北京市医管局2018临床医学发展专项"扬帆"计划(XMLX201804); 2020首都卫生发展科研专项(首发2020-2-2053)

Focusing on the screenning, diagnosis and treatment of pediatric vitreoretinal disease

Hai Lu1,†(), Jinghua Liu1, Yonghong Jiao1, Haicheng She1   

  1. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China
  • Received:2020-07-20 Published:2020-08-28
  • Corresponding author: Hai Lu
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卢海, 刘敬花, 焦永红, 佘海澄. 重视儿童眼底病的规范筛查、诊断和治疗[J]. 中华眼科医学杂志(电子版), 2020, 10(04): 193-197.

Hai Lu, Jinghua Liu, Yonghong Jiao, Haicheng She. Focusing on the screenning, diagnosis and treatment of pediatric vitreoretinal disease[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020, 10(04): 193-197.

儿童眼底病早期不易被发现，且诊断和治疗难度大，易导致患儿视功能永久不可逆性损害。该类疾病对眼底筛查的依赖程度较高，且儿童患者常常不配合常规眼科检查，儿童眼底病疾病谱和发病机制等有别于成人眼底病患者。因此，在筛查、检查、诊断和治疗方面，儿童眼底病都有异于成人患者的特点所在，应予以特别重视。本文中笔者对儿童眼底病的规范筛查、诊断和治疗等方面进行述评。

关键词: 儿童, 眼底病, 筛查, 诊断, 治疗

Pediatric vitreoretinal diseases can be easily neglected in the early stage, and are much more difficult to diagnosis and treat, which may result in poor and non-reversible prognosis. Pediatric patients with vitreoretinal diseases are different from adult patients in both disease spectrum and pathogenesis. Therefore, much more attention should be paid on the screening, diagnosis, examination and treatment of pediatric vitreoretinal diseases, which reviewd in this paper.

Key words: Pediatric, Fundus, Screening, Diagnosis, Treatment
[1]
Chen Y, Li X. Characteristics of severe retinopathy of prematurity patients in China: a repeat of the first epidemic？[J]. Br J Ophthalmol, 2006, 90(3): 268-271.
[2]
Gilbert C. Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control[J]. Early Hum Dev, 2008, 84(2): 77-82.
[3]
Liu J, Zhao P. lamellar macular hole with lamellar hole-associated epiretinal proliferation in familial exudative vitreoretinopathy[J]. Retin Cases Brief Rep, 2018, Online ahead of print. PMID: 30134364
[4]
Shields JA, Shields CL, Honavar SG, et al. Clinical variations and complications of Coats disease in 150 cases: the 2000 Sanford Gifford Memorial Lecture[J]. Am J Ophthalmol, 2001, 131(5): 561-571.
[5]
Solebo AL, Russell-Eggitt I, Cumberland P, et al. Congenital cataract associated with persistent fetal vasculature: findings from IoLunder2[J]. Eye (Lond), 2016, 30(9): 1204-1209.
[6]
Saab MG, Cordahi GP, Rezende FA. Fibrin sealant in the treatment of retinal detachment in morning glory syndrome[J]. Retin Cases Brief Rep, 2011, 5(4): 326-329.
[7]
储昭节，王雨生. 我国大陆地区近20年早产儿视网膜病变发病概况[J]. 中华眼科杂志，2012，48(2):179-183.
[8]
朱文珲，骆荣江，刘韶瑞. 高危新生儿眼底出血临床分析[J]．中华眼底病杂志，2012，28(5):482-484.
[9]
潘建东，黄崇斌，陈峰，等. 新生儿视网膜出血及其相关影响因素观察分析[J]．中华眼底病杂志，2013，29(3):280-283.
[10]
Watts P, Maguire S, Kwok T, et al. Newborn retinal hemorrhages: a systematic review[J]. J AAPOS, 2013, 17(1): 70-78.
[11]
Committee on Practice and Ambulatory Medicine, Section on Ophthalmology. American Association of Certified Orthoptists; American Association for Pediatric Ophthalmology and Strabismus; American Academy of Ophthalmology. Eye examination in infants, children, and young adults by pediatricians[J]. Pediatrics, 2003, 111(4): 902-907.
[12]
Solebo AL, Teoh L, Rahi J. Epidemiology of blindness in children[J]. Arch Dis Child, 2017 ，102(9): 853-857.
[13]
Muhit M, Karim T, Islam J, et al. The epidemiology of childhood blindness and severe visual impairment in Indonesia[J]. Br J Ophthalmol, 2018, 102(11): 1543-1549.
[14]
Jauregui R, Cho GY, Takahashi VKL, et al. Caring for Hereditary Childhood Retinal Blindness[J]. Asia Pac J Ophthalmol (Phila), 2018, 7(3): 183-191.
[15]
Tabarez-Carvajal AC, Montes-Cantillo M, Unkrich KH, et al. Retinopathy of prematurity: screening and treatment in Costa Rica[J]. Br J Ophthalmol, 2017, 101(12): 1709-1713.
[16]
Dogra MR, Katoch D, Dogra M. An Update on Retinopathy of Prematurity (ROP)[J]. J Pediatr, 2017, 84(12): 930-936.
[17]
Edwards EM, Horbar JD. Retinopathy of prematurity prevention, screening and treatmentprogrammes: The role of neonatal networks[J]. Semin Perinatol, 2019, 43(6): 341-343.
[18]
朱苾丹，李绍军. 我国早产儿视网膜病变筛查及治疗现状[J]. 中国斜视与小儿眼科志，2019，27(3):44-47.
[19]
王雨生，李蓉. 早产儿视网膜病变研究现状与趋势[J]. 国际眼科纵览，2010，34(1):1-5.
[20]
单海冬，赵培泉，蒋定锋. 严重早产儿视网膜病变危险因素分析[J]. 中华眼底病杂志，2005，21(5):271-274.
[21]
常青，江睿，罗晓刚，等. 上海早产儿视网膜病变年度筛查报告[J]. 中华眼底病杂志，2008，24(1):35-37.
[22]
朱丽，陈超，石文静，等. 早产儿视网膜病多中心筛查及发病率调查[J]. 中华围产医学杂志，2006，9(6):369-372.
[23]
王小军. 早产儿视网膜病变发病因素探讨[J]. 中国斜视与小儿眼科杂志，2008，16(3):125-126.
[24]
童林利，熊永强，林春堤，等. 新生儿眼底疾病筛查结果及早产儿视网膜病变高危因素分析[J]. 中国妇幼保健，2018，33(18):4262-4265.
[25]
姜燕荣，黎晓新，齐慧君，等. 早产儿视网膜病变发病因素探讨[J]. 中华眼科杂志，1994，30(6):427-430.
[26]
Bas AY, Demirel N, Koc E, et al. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units[J]. Br J Ophthalmol, 2018, 102(12): 1711-1716.
[27]
Akkawi MT, Shehadeh MM, Shams ANA, et al. Incidence and risk factors of retinopathy of prematurity in three neonatal intensive care units in Palestine[J]. BMC Ophthalmol, 2019, 19(1): 189.
[28]
Quinn GE, Ying GS, Bell EF, et al. Incidence and Early Course of Retinopathy of Prematurity: Secondary Analysis of the Postnatal Growth and Retinopathy of Prematurity (G-ROP) Study[J]. JAMA Ophthalmol, 2018, 136(12): 1383-1389.
[29]
Leng Y, Huang W, Ren G, et al. The treatment and risk factors of retinopathy of prematurity in neonatal intensive care units[J]. BMC Ophthalmol, 2018 , 18(1): 301.
[30]
王平，陶利娟，杨慧玲，等. 1069例新生儿眼底检查结果及分析[J]．中国实用眼科杂志，2007，25(10):1117-1119.
[31]
Li LH, Li N, Zhao JY, et al. Findings of perinatal ocular examination performed on 3573, healthy full-term newborns[J]. Br J Ophthalmol, 2013, 97(5): 588-591.
[32]
Early Treatment For Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial[J]. Arch Ophthalmol, 2003，121(12): 1684-1694.
[33]
项道满，陈锋，毛娅妮，等. 计算机辅助间接检眼镜下正常早产儿眼底与早产儿视网膜病变的特征观察[J]. 中华眼底病杂志，2008，24(1):26-29.
[34]
Laws DE, Morton C, Weindling M, el al. Systemic effects of screening for retinopathy of prematurity[J]. Br J Ophthalmol, 1996, 80(5): 425-428.
[35]
Mukherjee AN, Watts P, Al-Madfai H, et al. Impact of retinopathy of prematurity screening examination on cardio-respiratory indices: a comparison of indirect ophthalmoscopy and retcam imaging[J]. Ophthalmology, 2006, 113(9): 1547-1552.
[36]
Shah PK, Narendran V, Saravanan VR, et al. Screening for retinopathy of prematurity-a comparison between binocular indirect ophthalmoscopy and RetCam 120[J]. Indian J Ophthalmol, 2006, 54(1): 35-38.
[37]
Scott KE, Kim DY, Wang L, et al. Telemedical diagnosis of retinopathy of prematurity intraphysician agreement between ophthalmoscopic examination and image-based interpretation[J]. Ophthalmology, 2008, 115(7): 1222-1228.
[38]
卫生部. 关于印发早产儿治疗用氧和视网膜病变防治指南的通知[DB/OL]. 2010-12-2]．

URL    
[39]
布娟，林淑芳，庞宏蕾，等. RetCam Ⅱ小儿视网膜检查系统在婴幼儿眼底病筛查中的应用[J]．临床眼科杂志，2010，18(1):29-31.
[40]
田汝银，张国明，谢昊，等. 标准方位眼底摄像技术在早产儿视网膜病变远程筛查中的应用[J]．眼科新进展，2019，39(6):568-570.
[41]
Tsao PN, Teng RJ, Wu TJ, et al. Early outcome of extremely low birth weight infants in Taiwan[J]. J Formos Med Assoc, 1998, 97(7): 471-476.
[42]
Gilbert C, Rahi J, Eckstein M, et al. Retinopathy of prematurity in middle-income countries[J]. Lancet, 1997, 350(9070): 12-14.
[43]
北京早产儿视网膜病变流行病学调查组. 北京早产儿视网膜病变筛查和高危因素分析[J]. 中华眼底病杂志，2008, 24(1):30-34.
[44]
常青，江睿，罗晓刚，等. 上海早产儿视网膜病变年度筛查报告[J]. 中华眼底病杂志，2008, 24(1):35-37.
[45]
张国明，曾键，黄丽娜，等. 深圳早产儿视网膜病变筛查结果分析[J]．中华眼底病杂志，2008, 24(1):38-40.
[46]
王雨生. 我国早产儿视网膜病变三级防治网建设的设想与实践[J]. 中华眼底病杂志，2014, 30(1):6-8.
[47]
胡守龙，郑朝攀，崔燕辉，等. 双眼异时性视网膜母细胞瘤21例临床分析[J]. 眼科新进展，2020，40(6):559-561.
[48]
Carvill GL, Heavin SB, Yendle SC, et al. Targeted resequencing in epileptic encephalaopathies identifies de novo mutations in CHD2 and SYNGAP [J]. Nat Genet, 2013, 45(7): 825-830.
[49]
Shendure J, Ji H. Next-generation DNA sequencing[J]. Nat Biotechnol, 2008, 26(10): 1135-1145.
[50]
张婧，邓光达，赵琦，等. 家族性渗出性玻璃体视网膜病变误漏诊病例分析[J]．眼科，2019，28(5):354-358.
[51]
李杨. 遗传性眼病致病基因突变分析中应重视临床表型的评估[J]. 中华实验眼科杂志，2017，35(8):673-676.
[52]
Wang F, Wang H, Tuan HF, et al. Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements[J]. Hum Genet, 2014, 133(3): 331-345.
[53]
Liu J, Li S, Deng G, et al. Outcomes of secondary sulcus intraocular lens implantation in unilateral anterior persistent fetal vasculature[J]. Int J Ophthalmol, 2019, 12(4): 592-596.
[54]
Liu JH, Lu H, Li SF, et al. Outcomes of small gauge pars plicata vitrectomy for patients with persistent fetalvasculature: a report of 105 cases[J]. Int J Ophthalmol, 2017, 10(12): 1851-1856.
[55]
Vasavada AR, Vasavada SA, Bobrova N, et al. Outcomes of pediatric cataract surgery in anterior persistent fetal vasculature[J]. J Cataract Refract Surg, 2012, 38(5): 849-857.
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