切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2019, Vol. 09 ›› Issue (01) : 56 -60. doi: 10.3877/cma.j.issn.2095-2007.2019.01.009

综述

干燥综合征与肠道菌群相关性研究进展
刘雨诗1, 江晓丹1, 郝然1, 李学民1,()   
  1. 1. 100191 北京大学第三医院眼科
  • 收稿日期:2019-01-26 出版日期:2019-02-28
  • 通信作者: 李学民
  • 基金资助:
    首都卫生发展科研专项项目(首发2018-2-4093)

Research progress of relation between Sjögren's syndrome and gut microbiota

Yushi Liu1, Xiaodan Jiang1, Ran Hao1, Xuemin Li1,()   

  1. 1. Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China
  • Received:2019-01-26 Published:2019-02-28
  • Corresponding author: Xuemin Li
引用本文:

刘雨诗, 江晓丹, 郝然, 李学民. 干燥综合征与肠道菌群相关性研究进展[J/OL]. 中华眼科医学杂志(电子版), 2019, 09(01): 56-60.

Yushi Liu, Xiaodan Jiang, Ran Hao, Xuemin Li. Research progress of relation between Sjögren's syndrome and gut microbiota[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(01): 56-60.

肠道菌群在人体免疫系统中发挥着重要作用,肠道菌群及其代谢物的异常与一系列免疫性疾病密切相关。干燥综合征作为自身免疫性疾病的一种,其发病可能与多种因素相关。近年来的一系列研究提示肠道菌群通过调节肠道局部与全身免疫反应,会对干燥综合征的发生与发展产生重要影响。本文中笔者对干燥综合征患者的肠道菌群改变、肠道菌群对干燥综合征的影响及二者可能的免疫学联系进行阐述。

The gut microbiota plays a critical role in the human immune system, and abnormalities of the intestinal flora and its metabolites are closely related to a series of systemic autoimmune diseases. Sj?gren's syndrome is one of the most common autoimmune disease whose onset may be relevant to a variety of factors. Over the recent years, emerging studies are suggesting that gut microbiota may be correlated with the occurrence or development of Sj?gren's syndrome, through profoundly affecting the local and systemic immune responses. This review describes the gut microbiota changes in patients with Sj?gren's syndrome, as well as itseffects on the disease and the possible immunological pathogenesis.

[1]
Zhong D, Wu C, Zeng X, et al. The role of gut microbiota in the pathogenesis of rheumatic diseases [J]. Clin Rheumatol, 2018, 37(1): 25-34.
[2]
Clemente JC, Manasson J, Scher JU. The role of the gut microbiome in systemic inflammatory disease [J]. Bmj, 2018, 360: j5145.
[3]
Fox RI. Sjogren's syndrome [J]. Lancet, 2005, 366(9482): 321-331.
[4]
中华医学会风湿病学分会. 干燥综合征诊断及治疗指南[J]. 中华风湿病学杂志2010, 14(11): 766-768.
[5]
Vivino FB. Sjogren's syndrome: Clinical aspects [J]. Clin Immunol, 2017, 182: 48-54.
[6]
Kuklinski E, Asbell PA. Sjogren's syndrome from the perspective of ophthalmology [J]. Clin Immunol, 2017, 182: 55-61.
[7]
Tapinos NI, Polihronis M, Tzioufas AG, et al. Sjogren's syndrome Autoimmune epithelitis [J]. Adv Exp Med Biol, 1999, 455: 127-134.
[8]
Goules AV, Kapsogeorgou EK, Tzioufas AG. Insight into pathogenesis of sjogren's syndrome: dissection on autoimmune infiltrates and epithelial cells [J]. Clin Immunol, 2017, 182: 30-40.
[9]
Takeda K, Kaisho T, Akira S. Toll-like receptors [J]. Annu Rev Immunol, 2003, 21: 335-376.
[10]
Jonsson R, Gordon TP, Konttinen YT. Recent advances in understanding molecular mechanisms in the pathogenesis and antibody profile of Sjogren's syndrome [J]. Curr Rheumatol Rep, 2003, 5(4): 311-316.
[11]
Sawalha AH, Potts R, Schmid WR, et al. The genetics of primary Sjogren's syndrome [J]. Curr Rheumatol Rep, 2003, 5(4): 324-332.
[12]
Tzioufas AG, Kapsogeorgou EK, Manoussakis MN, et al. Pathogenetic aspects of primary sjögren's syndrome[M]. London: Springer, 2011: 33-53.
[13]
Kverka M, Tlaskalova-Hogenova H. Intestinal microbiota: facts and fiction [J]. Dig Dis, 2017, 35(1-2): 139-147.
[14]
Rajilic-Stojanovic M, de Vos WM. The first 1000 cultured species of the human gastrointestinal microbiota [J]. FEMS Microbiol Rev, 2014, 38(5): 996-1047.
[15]
Koboziev I, Reinoso WC, Furr KL, et al. Role of the enteric microbiota in intestinal homeostasis and inflammation [J]. Free Radic Biol Med, 2014, 68: 122-133.
[16]
Clooney AG, Fouhy F, Sleator RD, et al. Comparing apples and oranges? next generation sequencing and Its Impact on microbiome analysis [J]. PLoS One, 2016, 11(2): e0148028.
[17]
Bouskra D, Brezillon C, Berard M, et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis [J]. Nature, 2008, 456(7221): 507-510.
[18]
Moreau MC, Corthier G. Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice [J]. Infect Immun, 1988, 56(10): 2766-2768.
[19]
Pabst O, Herbrand H, Friedrichsen M, et al. Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling [J]. J Immunol, 2006, 177(10): 6824-6832.
[20]
Ivanov, I, Frutos Rde L, Manel N, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine [J]. Cell Host Microbe, 2008, 4(4): 337-349.
[21]
Ivanov, I, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria [J]. Cell, 2009, 139(3): 485-498.
[22]
Geuking MB, Cahenzli J, Lawson MA, et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses [J]. Immunity, 2011, 34(5): 794-806.
[23]
Fagarasan S, Kawamoto S, Kanagawa O, et al. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis [J]. Annu Rev Immunol, 2010, 28: 243-273.
[24]
Peterson DA, Mcnulty NP, Guruge JL, et al. IgA response to symbiotic bacteria as a mediator of gut homeostasis [J]. Cell Host Microbe, 2007, 2(5): 328-339.
[25]
Mora JR, Iwata M, Eksteen B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells [J]. Science, 2006, 314(5802): 1157-1160.
[26]
Sonnenberg GF, Artis D. Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease [J]. Immunity, 2012, 37(4): 601-610.
[27]
Fukuda S, Toh H, Hase K, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate [J]. Nature, 2011, 469(7331): 543-547.
[28]
Petersson J, Schreiber O, Hansson GC, et al. Importance and regulation of the colonic mucus barrier in a mouse model of colitis [J]. Am J Physiol Gastrointest Liver Physiol, 2011, 300(2): G327-G333.
[29]
Fagundes CT, Amaral FA, Vieira AT, et al. Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice [J]. J Immunol, 2012, 188(3): 1411-1420.
[30]
Kamada N, Seo SU, Chen GY, et al. Role of the gut microbiota in immunity and inflammatory disease [J]. Nat Rev Immunol, 2013, 13(5): 321-335.
[31]
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system [J]. Science, 2012, 336(6086): 1268-1273.
[32]
Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease [J]. Cell Microbiol, 2014, 16(7): 1024-1033.
[33]
徐凤,张焕容,张兴民,等. 不同年龄山羊胃肠道乳酸菌的分离鉴定[J]. 黑龙江畜牧兽医2017(3):108-110.
[34]
聂远洋,邓岳,刘戎梅,等. 不同年龄麦洼牦牛肠道菌群的分离鉴定及其群落结构的变化[J]. 中国测试201642(12):53-59.
[35]
黄皓,郝丽,肖向红,等. 肠道菌群功能及检测技术研究进展[J]. 黑龙江畜牧兽医201861(13):48-51.
[36]
郑艺,张家超,张和平. 基于高通量测序技术分析肠道菌群及其影响因素的研究进展[J]. 中国食品学报201414(11):157-164.
[37]
钟海波,伍哓锋,曾瑜,等. 多重耐药鲍曼不动杆菌ERIC-PCR的分子流行病学研究[J]. 现代医院201313(12):19.
[38]
Gnat S, Malek W, Olenska E, et al. Insight into the genomic diversity and relationship of Astragalus glycyphyllos symbionts by RAPD, ERIC-PCR, and AFLP fingerprinting[J]. Journal of Applied Genetics, 2015, 56(4): 551-554.
[39]
Torriani S, Clementi F, Vancanneyt M, et al. Differentiation of Lactobacillus plantarum, L. pentosus and L. paraplantarum species by RAPD-PCR and AFLP[J]. Systematic & Applied Microbiology, 2001, 24(4): 554-558.
[40]
Gueimonde M, Debor L, Tölkkö S, et al. Quantitative assessment of faecal bifidobacterial populations by real-time PCR using lanthanide probes[J]. J Appl Microbiol, 2007, 102(4): 1116-1122.
[41]
Relman DA, Schmidt TM, Macdermott RP, et al. Identification of the uncultured bacillus of Whipple's disease[J]. N Engl J Med, 1992, 327(5): 293-297.
[42]
Romano KA, Dillmcfarland KA, Kasahara K, et al. Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation[J]. Microbiome, 2018, 6(1): 91-96.
[43]
Nai C, Meyer V. From axenic to mixed cultures:technological advances accelerating a paradigm shift in microbiology[J]. Trends Microbiol, 2018, 26(6): 538-554.
[44]
庄琪琛,宁芮之,麻远,等. 微流控技术应用于细胞分析的研究进展[J]. 分析化学201644(4):522-532.
[45]
Chiron C, Tompkins TA, Burguière P. Flow cytometry: a versatile technology for specific quantification and viability assessment of microorganisms in multi-strain probiotic products[J].Journal of Applied Microbiology, 2017: 572-584.
[46]
de Paiva CS, Jones DB, Stern ME, et al. Altered mucosal microbiome dversity and disease severity in sjogren syndrome [J]. Sci Rep, 2016, 6: 23561.
[47]
Mandl T, Marsal J, Olsson P, et al. Severe intestinal dysbiosis is prevalent in primary Sjogren's syndrome and is associated with systemic disease activity [J]. Arthritis Res Ther, 2017, 19(1): 237.
[48]
Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells [J]. Nature, 2013, 504(7480): 446-450.
[49]
Miquel S, Martin R, Rossi O, et al. Faecalibacterium prausnitzii and human intestinal health [J]. Curr Opin Microbiol, 2013, 16(3): 255-261.
[50]
Sharma R, Zheng L, Guo X, et al. Novel animal models for Sjogren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice [J]. J Autoimmun, 2006, 27(4): 289-296.
[51]
Szymula A, Rosenthal J, Szczerba BM, et al. T cell epitope mimicry between sjogren's syndrome antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria [J]. Clin Immunol, 2014, 152(1-2): 1-9.
[52]
Wang C, Zaheer M, Bian F, et al. Sjogren-like lacrimal keratoconjunctivitis in germ-free mice [J]. Int J Mol Sci, 2018, 19(2): 565-569.
[53]
Zaheer M, Wang C, Bian F, et al. Protective role of commensal bacteria in sjogren syndrome [J]. J Autoimmun, 2018, 93: 45-56.
[54]
He B, Hoang TK, Wang T, et al. Resetting microbiota by lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors [J]. J Exp Med, 2017, 214(1): 107-123.
[55]
Waidmann M, Bechtold O, Frick JS, et al. Bacteroides vulgatus protects against escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice [J]. Gastroenterology, 2003, 125(1): 162-177.
[56]
van der Meulen TA, Harmsen H, Bootsma H, et al. The microbiome-systemic diseases connection [J]. Oral Dis, 2016, 22(8): 719-734.
[1] 杨瑾, 刘雪克, 张媛媛, 金钧, 韦瑶. 肠道微生物来源石胆酸对脓毒症相关肝损伤的保护作用[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 265-274.
[2] 戴睿, 张亮, 陈浏阳, 张永博, 吴丕根, 孙华, 杨盛, 孟博. 肠道菌群与椎间盘退行性变相关性的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 546-549.
[3] 李嘉兴, 孙乙文, 李文星. NLRP3炎性小体在急性胰腺炎中作用的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(04): 300-304.
[4] 李玲, 刘亚, 李培玲, 张秀敏, 李萍. 直肠癌患者术后肠道菌群的变化与抑郁症相关性研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 607-610.
[5] 王雪玲, 曹欢, 顾劲扬. 肠道菌群在器官缺血再灌注损伤中的作用及机制研究进展[J/OL]. 中华移植杂志(电子版), 2024, 18(04): 247-250.
[6] 方道成, 唐春华, 胡媛媛. 肠道菌群对草酸钙肾结石形成的影响[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 509-513.
[7] 蔡艺丹, 方坚, 张志强, 陈莉, 张世安, 夏磊, 阮梅, 李东良. 经颈静脉肝内门体分流术对肝硬化门脉高压患者肠道菌群及肝功能的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 285-293.
[8] 张龙, 孙善柯, 徐伟, 李文柱, 李俊达, 池涌泉, 何广胜, 成峰, 王学浩, 饶建华. 腹腔镜脾切除治疗血液系统疾病的临床疗效分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 870-875.
[9] 王天福, 王刚. 自身免疫性胰腺炎诊治现状[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 492-497.
[10] 白睿, 孙备. 自身免疫性胰腺炎和胰腺导管腺癌鉴别的策略与思考[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(02): 121-126.
[11] 赵小民, 杨军, 田巍巍. 枳术颗粒联合利那洛肽治疗便秘型肠易激综合征的临床研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 465-469.
[12] 邱岭, 朱旭丽, 浦坚, 邢苗苗, 吴佳玲. 糖尿病肾病患者肠道菌群生态特点与胃肠道功能障碍的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 453-458.
[13] 宋燕秋, 戚桂艳, 杨双双, 周萍. 重症急性胰腺炎肠道菌群特征及早期肠内营养联合微生态制剂治疗的临床价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 442-447.
[14] 韦美菊, 潘玲. 肠道菌群-胆汁酸代谢轴在慢性肾脏病中的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(02): 219-222.
[15] 刘昌恩, 李岩, 张其德. 基于内镜筛查发现的自身免疫性胃炎的临床特征分析[J/OL]. 中华胃肠内镜电子杂志, 2024, 11(04): 233-237.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?