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中华眼科医学杂志(电子版) ›› 2025, Vol. 15 ›› Issue (03) : 183 -187. doi: 10.3877/cma.j.issn.2095-2007.2025.03.010

综述

化学战剂损伤的眼部表现与治疗的研究进展
刘涵, 沈强, 方晏红, 彭小静()   
  1. 402260 重庆市江津区中心医院(重庆大学附属江津医院)眼科
  • 收稿日期:2025-04-27 出版日期:2025-06-28
  • 通信作者: 彭小静
  • 基金资助:
    重庆市自然科学基金项目(CSTB2024NSCQ-MSX0248 ,CSTB2023NSCQ-MSX1061); 2023年重庆市公共卫生重点专科(学科)建设项目(渝卫办发〔2023〕81号); 重庆市江津区科学技术局项目(Y2023016)

Research progress on the ocular manifestations and treatment of chemical warfare agents injury

Han Liu, Qiang Shen, Yanhong Fang, Xiaojing Peng()   

  1. Department of Ophthalmology, Chongqing University Jiangjin Hospital (Jiangjin Central Hospital of Chongqing), Chongqing 402260, China
  • Received:2025-04-27 Published:2025-06-28
  • Corresponding author: Xiaojing Peng
引用本文:

刘涵, 沈强, 方晏红, 彭小静. 化学战剂损伤的眼部表现与治疗的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(03): 183-187.

Han Liu, Qiang Shen, Yanhong Fang, Xiaojing Peng. Research progress on the ocular manifestations and treatment of chemical warfare agents injury[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2025, 15(03): 183-187.

对于战争或者武装冲突,化学战一直是潜在的威胁。化学战剂会作用于全身或一些特定的器官,造成一定的不可逆性损害,眼部也会有相应的急性或者慢性表现。美国疾病控制和预防中心将化学毒剂分为糜烂性毒剂、神经性毒剂、窒息性毒剂、腐蚀剂、血液毒剂、致残剂、金属毒剂、防暴剂、有毒酒精及生物毒素等10类。糜烂性毒剂包括芥子毒气、路易氏气及光气肟;窒息性毒剂包括光气和氯化苦。糜烂性毒剂暴露可造成眼表刺激,重症者可引起角膜混浊、角膜溃疡及角膜水肿;神经性毒剂暴露可引起瞳孔缩小、视力下降及眼泪分泌增多;防暴剂暴露可导致流泪、结膜充血、眼睑痉挛、畏光、结膜炎及眶周水肿。在化学战剂暴露后,急诊处理的原则主要是脱离中毒环境,主要的治疗手段包括解毒治疗、局部滴眼液及眼表重建等。本文中笔者就化学战剂的眼部表现与治疗策略进行综述。

Chemical warfare has always been a potential threat to war or armed conflict. Chemical warfare agents act on the whole body or specific organs, causing irreversible damage and corresponding acute or chronic ocular manifestations. The Centers for Disease Control and Prevention in the United States classifies chemical agents into 10 categories: corrosive agents, nerve agents, asphyxiating agents, corrosives, blood agents, disabling agents, metal agents, riot control agents, toxic alcohol, and biotoxins. Corrosive toxins include mustard gas, Louis gas, and phosgene oxime; asphyxiant toxins include phosgene and chloropicrin. The irritation to the ocular surface could be caused after exposure to erosive toxins, and in severe cases, for corneal opacity, corneal ulcers, and corneal edema; the pupil constriction, blurred vision, and increased tear secretion after exposure to nerve agents; the tearing, conjunctival congestion, blepharospasm, photophobia, conjunctivitis, and periorbital edema after exposure to riot control agents. After exposure to chemical warfare agents, emergency treatment mainly involves leaving the toxic environment, and the main treatment methods include detoxification treatment, local eye drops, and ocular surface reconstruction. The ocular manifestations and treatment strategies of chemical warfare agents was reviewed in this paper.

表1 化学战剂的眼部表现及治疗策略的文献汇总
化学战剂名称 眼部表现或治疗策略 参考文献
芥子毒气 眼部表现  
  (1)低剂量暴露时结膜角膜炎症和眼部刺激征,中剂量暴露时表现为眼部疼痛、角膜水肿及角膜大泡形成及暂时失明,高剂量暴露时表现为葡萄膜炎、结膜坏死、角膜缘坏死、角膜溃疡甚至永久失明 [4]
  (2)轻症表现为持续的眼表刺激症,重症表现为角膜混浊、角膜溃疡、角膜水肿、带状角膜变性及角膜融解伴新生血管形成 [5]
  (3)严重的角膜基质层水肿和角膜瘢痕形成,包括持续性上皮缺损、角膜缘干细胞缺乏、角膜新生血管形成及干眼 [6]
  治疗策略  
  (1)立即使用大量清水冲洗双眼,使用局部润滑剂擦拭,但不推荐使用油性脂质润滑剂 [7]
  (2)抗生素预防感染,人工泪液缓解干眼,自体血清促进角膜愈合,羊膜移植术 [10]
路易氏气 急性眼部症状包括眼痛、流泪、眼睑痉挛及水肿,大剂量暴露可发生角膜水肿和新生血管形成 [14]
光气肟 低剂量接触会导致眼部刺激和剧烈疼痛并伴有眼睑水肿、流泪、结膜炎、眼睑痉挛、炎症及暂时性失明,高剂量或长时间暴露可导致角膜炎、虹膜炎、角膜穿孔、永久性角膜病变及失明 [18]
神经性毒剂 主要症状是瞳孔缩小和流泪,其他症状包括睫状肌收缩、痉挛,视力下降及短暂性近视,并伴有眼痛,治疗主要是阿托品散瞳和治疗虹膜炎症 [21]
光气 眼部灼痛、流泪及结膜潮红等,治疗主要是眼部冲洗 [29]
氯化苦 (1)眼部炎症、角膜水肿、眼组织损伤及视觉损伤 [31]
  (2)小鼠实验发现轻度氯化苦暴露可导致角膜溃疡和眼睑肿胀,重症可导致的角膜混浊和新生血管形成,甚至出现角膜大疱以及前房积血 [33]
  (3)活体兔实验发现超饱和氧乳液可减轻角膜损伤 [34]
催泪瓦斯 临床表现  
  常见的临床表现包括流泪、结膜充血、眼睑痉挛、畏光、结膜炎及眶周水肿,重症包括葡萄膜炎、坏死性角膜炎、继发性青光眼、白内障、外伤性视神经病变及失明 [38]
  治疗策略  
  (1)暴露后立即清水或盐水大量冲洗,可使用表面麻醉剂来减轻疼痛和眼睑痉挛,两性螯合冲洗液对眼部冲洗也有效,全身性皮质类固醇可以减轻炎症用于严重化学损伤 [39]
  (2)敌腐特灵对催泪瓦斯有独特的效果,可以减少角膜间质水肿,减少后期角膜白斑的发生率 [32]
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