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中华眼科医学杂志(电子版) ›› 2024, Vol. 14 ›› Issue (06) : 375 -379. doi: 10.3877/cma.j.issn.2095-2007.2024.06.010

综述

蛋白质组学在糖尿病相关眼病中作用的研究进展
韩雨桐1, 丁宁1, 吴霞1, 甘丽祯1, 陈正国2, 吴云川1, 韦庆波1,()   
  1. 1.210023 南京中医药大学针灸推拿学院·养生康复学院推拿学教研室
    2.210029 南京市鼓楼区华侨路社区卫生服务中心中医科
  • 收稿日期:2024-09-03 出版日期:2024-12-28
  • 通信作者: 韦庆波
  • 基金资助:
    国家自然科学基金青年项目(82205259,82305377)江苏省自然科学基金青年项目(BK20230455)南京市中医药科技专项项目(ZYYB202229)南京中医药大学国自然青年基金经费配套项目(XPT82205259)

Advances on the role of proteomics in diabetes-related eye diseases

Yutong Han1, Ning Din1, Xia Wu1, Lizhen Gan1, Zhengguo Chen2, Yunchuan Wu1, Qingbo Wei1,()   

  1. 1.Nanjing University of Chinese Medicine,School of Acupuncture and Massage,School of Health Rehabilitation,Teaching and Research Department of Massage,Nanjing 210023,China
    2.Huaqiao Road Community Health Service Center,Department of traditional Chinese Medicine,Gulou District,Nanjing 210029,China
  • Received:2024-09-03 Published:2024-12-28
  • Corresponding author: Qingbo Wei
引用本文:

韩雨桐, 丁宁, 吴霞, 甘丽祯, 陈正国, 吴云川, 韦庆波. 蛋白质组学在糖尿病相关眼病中作用的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(06): 375-379.

Yutong Han, Ning Din, Xia Wu, Lizhen Gan, Zhengguo Chen, Yunchuan Wu, Qingbo Wei. Advances on the role of proteomics in diabetes-related eye diseases[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(06): 375-379.

蛋白质组学是一门重点研究疾病发病机制、早期诊断、针对性治疗及预后的学科。近年来,蛋白质组学技术在糖尿病及其并发症中的应用亦日趋广泛。糖尿病相关眼病包括糖尿病性视网膜病变(DR)、糖尿病性黄斑水肿(DME)、糖尿病性干眼、糖尿病性白内障及新生血管性青光眼(NVG)等。本文中笔者主要从蛋白质组学在糖尿病相关眼病的发病机制、诊断及生物标志物等方面进行综述。

Proteomics is a discipline that focuses on the pathogenesis,early diagnosis,targeted treatment and prognosis of diseases.In recent years,with the development and maturity of proteomics technology,its application in diabetes and its complications is becoming more and more extensive.Diabetic eye diseases include diabetic retinopathy(DR),diabetic macular edema(DME),diabetic dry eye,diabetic cataract and neovascular glaucoma(NVG).The role of proteomics in the pathogenesis,diagnosis and biomarkers of diabetes-related eye diseases were reviewed in this paper.

[1]
International Diabetes Federation.IDF Diabetes Atlas,10th edn[EB/OL].(2021-9-12) [2022-3-17].https://www.diabetesatlas.org.
[2]
中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志,2021,13(4):315-409.
[3]
卫军营,钱小红.蛋白质组学研究技术进展[J].中华检验医学杂志,2009,32(2):137-141.
[4]
Zhan X,Li B,Zhan X,et al.Innovating the concept and practice of two-dimensional gel electrophoresis in the analysis of proteomes at the proteoform level[J].Proteomes,2019,7(4):36.
[5]
韦庆波,高卫萍,赵凡,等.蛋白质组学在干眼症研究中的应用进展[J].辽宁中医杂志,2019,46(2):429-431.
[6]
韦庆波,丁宁,杨小存,等.蛋白质组学技术在干眼研究及针刺治疗干眼中的应用[J].国际眼科杂志,2024,24(1):58-61.
[7]
许光军,张学东.蛋白质组学在糖尿病视网膜病变中的应用[J].眼科新进展,2011,31(4):391-393.
[8]
肖迎,唐仕波.视网膜疾病的蛋白质组研究[J].中华眼底病杂志,2005,21(3):199-202.
[9]
张凤.蛋白质组学核心技术研究综述[J].延安职业技术学院学报,2014,28(5):137-139.
[10]
黄啸.生物信息学在蛋白质组学上的应用[J].安徽农业科学,2006,34(23):6142-6144.
[11]
白建瑞.基于生物质谱技术的蛋白质组学研究[J].现代农业研究,2023,29(4):145-147.
[12]
Chen G,Yang L,Liu G,et al.Research progress in protein microarrays:Focussing on cancer research[J].PROTEOMICSClinical Applications,2023,17(1):2200036.
[13]
杜长虹,刘银萍.糖尿病视网膜病变发病机制研究进展[J].沈阳医学院学报,2023,25(1):88-91.
[14]
Yau JWY,Rogers SL,Kawasaki R,et al.Global prevalence and major risk factors of diabetic retinopathy[J].Diabetes Care,2012,35(3):556-564.
[15]
张媛,金玮,杨安怀.蛋白质组学应用于糖尿病视网膜病变发病机制的研究进展[J].临床眼科杂志,2017,25(6):569-572.
[16]
Ma JYW,Sze YH,Bian JF,et al.Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases(Review)[J].Int J Mol Med,2021,47(5):83.
[17]
CsöszÉ,Boross P,Csutak A,et al.Quantitative analysis of proteins in the tear fluid of patients with diabetic retinopathy[J].J Proteomics,2012,75(7):2196-2204.
[18]
Xiao H,Xin W,Sun LM,et al.Comprehensive proteomic profiling of aqueous humor proteins in proliferative diabetic retinopathy[J].Transl Vis Sci Technol,2021,10(6):3.
[19]
Chiang SY,Tsai ML,Wang CY,et al.Proteomic analysis and identification of aqueous humor proteins with a pathophysiological role in diabetic retinopathy[J].J Proteomics,2012,75(10):2950-2959.
[20]
Chen H,Qiu B,Gao G,et al.Proteomic changes of aqueous humor in proliferative diabetic retinopathy patients treated with different intravitreal anti-VEGF agents[J].Exp Eye Res,2022,216:108942.
[21]
Youngblood H,Robinson R,Sharma A, et al.Proteomic biomarkers of retinal inflammation in diabetic retinopathy[J].Int J Mol Sci,2019,20(19):4755.
[22]
Liu YP,Hu SW,Wu ZF,et al.Proteomic analysis of human serum from diabetic retinopathy[J].Int J Ophthalmol,2011,4(6):616.
[23]
Mishra D, Gade S, Glover K, et al.Vitreous humor:composition,characteristics and implication on intravitreal drug delivery[J].Curr Eye Res,2023,48(2):208-218.
[24]
Monteiro JP,Santos FM,Rocha AS,et al.Vitreous humor in the pathologic scope:insights from proteomic approaches[J].Proteomics Clin Appl,2015,9(1-2):187-202.
[25]
Balaiya S,Zhou Z,Chalam KV.Characterization of vitreous and aqueous proteome in humans with proliferativediabetic retinopathy and its clinical correlation[J].Proteomics Insights,2017,PMID:28469465.
[26]
李琦,张雯,张学东.增殖性糖尿病视网膜病变伴重度黄斑水肿玻璃体蛋白质组学初步研究[J].重庆医科大学学报,2010,35(7):1043-1047.
[27]
Alanazi AH,Shan S, Narayanan SP, et al.Comparative proteomic analysis of type 2 diabetic versus non-diabetic vitreous fluids[J].Life,2024,14(7):883.
[28]
Raposo G,Stahl PD.Extracellular vesicles-on the cusp of a new language in the biological sciences[J].EVCNA,2023,4(2):240.
[29]
Guo W,Liu W,Wang J,et al.Extracellular vesicles and macrophages in tumor microenvironment:Impact on cervical cancer[J].Heliyon,2024,10(15):1-12
[30]
Wang S,Xia K,Zhu X,et al.Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy[J].JChromatogr A,2024,1718:464700.
[31]
Xiao J,Zhang H,Yang F,et al.Proteomic analysis of plasma sEVs reveals that TNFAIP8 is a new biomarker of cell proliferation in diabetic retinopathy[J].J Proteome Res,2021,20(3):1770-1782.
[32]
Chee CS,Chang KM,Loke MF,et al.Association of potential salivary biomarkers with diabetic retinopathy and its severity in type-2 diabetes mellitus: a proteomic analysis by mass spectrometry[J].Peer J,2016,4:e2022.
[33]
杨维佳,贾俊,万鹏飞.活血利水方加减联合西药治疗糖尿病视网膜病变黄斑囊样水肿疗效观察[J].四川中医,2023,41(7):118-120.
[34]
Zhang J,Zhang J,Zhang C,et al.Diabetic macular edema:current understanding,molecular mechanisms and therapeutic implications[J].Cells,2022,11(21):3362.
[35]
Chen E,Looman M,Laouri M,et al.Burden of illness of diabetic macular edema:literature review[J].Curr Med Res Opin,2010,26(7):1587-1597.
[36]
Otani T,Kishi S,Maruyama Y.Patterns of diabetic macular edema with optical coherence tomography[J].Am JOphthalmol,1999,127(6):688-693.
[37]
Romero-Aroca P,Baget-Bernaldiz M,Pareja-Rios A,et al.Diabetic macular edema pathophysiology: vasogenic versus inflammatory[J].JProteome Res,2016,2016(1):2156273.
[38]
Zhang Y,Xu M,He H,et al.Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema[J].Exp Eye Res,2024,239:109724.
[39]
Ma IH,Hsieh YT,Pan SH.Explore the specific biomarkers for diabetic macular edema:a comparison study of tear proteomics[J].Investig Ophthalmol Vis Sci,2024,65(7):3325-3325.
[40]
张思伟,沈咏梅,叶山东,等.玻璃酸钠联合0.1%氟米龙治疗糖尿病性干眼症观察[J].临床眼科杂志,2019,27(5):454-457.
[41]
李泽楠,张宏.糖尿病性干眼发病机制的研究进展[J].中国医药科学,2024,14(6):59-63.
[42]
韦庆波,林佳,顾嘉凌,等.针灸治疗干眼症的临床与机制研究现状[J].中华中医药杂志,2021,36(1):319-323.
[43]
Zou X,Wang S,Zhang P,et al.Quantitative proteomics and weighted correlation network analysis of tear samples in adults and children with diabetes and dry eye[J].Transl Vis Sci Technol,2020,9(13):8.
[44]
Saxena S,Mitchell P,Rochtchina E.Five-year incidence of cataract in older persons with diabetes and pre-diabetes[J].Ophthalmic Epidemiol,2004,11(4):271-277.
[45]
Kiziltoprak H,Tekin K,Inanc M,et al.Cataract in diabetes mellitus[J].World J Diabetes,2019,10(3):140.
[46]
Chan LKY,Lin SS,Chan F,et al.Optimizing treatment for diabetic macular edema during cataract surgery[J].Front Endocrinol(Lausanne),2023,14:1106706.
[47]
郭俊豪.糖尿病性白内障患者血糖指标水平[J].吉林医学,2022,43(11):2961-2963.
[48]
Xu W,Liang Y,Zhu Y,et al.Proteomic study of aqueous humour in diabetic patients with cataracts by TMT combined with HPLC-MS/MS[J].BMC Ophthalmol,2023,23(1):435.
[49]
Chang WC,Lee CH,Chiou SH,et al.Proteomic analysis of aqueous humor proteins in association with cataract risks:Diabetes and smoking[J].JClin Med,2021,10(24):5731.
[50]
郭鑫,苏胜,刘平.1型和2型糖尿病性白内障和正常晶状体的蛋白质组学分析[J].哈尔滨医科大学学报,2015,49(4):313-316.
[51]
Nagai N,Yamamoto T,Mitamura K,et al.Proteomic profile of the lens in a streptozotocin induced diabetic rat model using shotgun proteomics[J].Biomedical Reports,2017,7(5):445-450.
[52]
Tang Y,Shi Y,Fan Z.The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy[J].Front Endocrinol,2023,14:1102361.
[53]
Madsen PH.Haemorrhagic glaucoma.Comparative study in diabetic and nondiabetic patients[J].Br J Ophthalmol,1971,55(7):444-450.
[54]
Lee P,Wang CC,Adamis AP.Ocular neovascularization:an epidemiologic review[J].Surv Ophthalmol,1998,43(3):245-269.
[55]
Wang Y,Xu S,Li J,et al.Proteomic analysis of aqueous humor proteins associated with neovascular glaucoma secondary to proliferative diabetic retinopathy[J].Current Proteomics,2021,18(5):717-729.
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