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中华眼科医学杂志(电子版) ›› 2024, Vol. 14 ›› Issue (05) : 316 -320. doi: 10.3877/cma.j.issn.2095-2007.2024.05.011

综述

转化生长因子β与糖尿病视网膜病变相关性的研究进展
刘涵1, 张蓝月1, 沈强1, 方晏红1, 周双2,()   
  1. 1.402260 重庆大学附属江津医院眼科
    2.402260 重庆市江津区中医院老年病科
  • 收稿日期:2024-08-27 出版日期:2024-10-28
  • 通信作者: 周双
  • 基金资助:
    重庆市自然科学基金面上项目(CSTB2024NSCQMSX0248,CSTB2023NSCQ-MSX1061,CSTB2023NSCQ-MSX0639)2023年重庆市公共卫生重点专科(学科)建设项目重庆市卫生健康委项目(2023WSJK149)重庆市江津区科学技术局项目(Y2023016)

Research progress in the correlation between transforming growth factor beta and diabetic retinopathy

Han Liu1, Lanyue Zhang1, Qiang Shen1, Yanhong Fang1, Shuang Zhou2,()   

  1. 1.Department of Ophthalmology,Chongqing University Jiangjin Hospital,Chongqing 402260,China
    2.Department of Geriatrics,Jiangjin District Hospital of Traditional Chinese Medicine,Chongqing 402260,China
  • Received:2024-08-27 Published:2024-10-28
  • Corresponding author: Shuang Zhou
引用本文:

刘涵, 张蓝月, 沈强, 方晏红, 周双. 转化生长因子β与糖尿病视网膜病变相关性的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(05): 316-320.

Han Liu, Lanyue Zhang, Qiang Shen, Yanhong Fang, Shuang Zhou. Research progress in the correlation between transforming growth factor beta and diabetic retinopathy[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(05): 316-320.

糖尿病会引起糖尿病视网膜病变(DR),是成年人致盲的重要病因。转化生长因子β(TGF-β)在眼部既具有促血管生成作用,又具有抗血管生成作用。有研究结果表明,TGF-β的稳态失衡参与了DR的发生与进展。高糖环境会导致TGF-β产生过多,并成为DR的致病因素,但生理量的TGF-β可能又是保护视网膜的因素。在DR的靶向治疗中,出现了从基因、分子、体外模型及动物实验的抗TGF-β或维持TGF-β稳态的治疗。我国传统医药和天然提取物中也有抗TGF-β的物质,可帮助DR患者改善病情。本文中笔者就TGF-β与DR的相关性以及DR的潜在抗TGF-β治疗进行综述,旨在为临床DR治疗与研究提供参考。

Diabetes causes diabetic retinopathy(DR),which is an important cause of blindness in adults.Transforming growth factorβ(TGF-β)has both pro-angiogenic and anti-angiogenic effects in the eye.It has demonstrated that the steady-state imbalance of TGF-β is involved in the occurrence and progression of DR.High-glucose environment leads to excessive production of TGF-β,which is a pathogenic factor causing DR.However,physiological levels of TGF-βmay also be a protective factor for the retina.In the targeted therapy of DR,anti-TGF-βor maintenance of TGF-βhomeostasis from genetic,molecular,in vitro models and animal experiments have emerged.Traditional Chinese medicine and natural extracts also contain anti TGF-β substances,which can help improve the condition of DR patients.The correlation between TGF-βand DR and the potential anti TGF-βtherapy for DR,with the aim of serving clinical DR treatment and research were reviewed in this paper.

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