切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (01) : 35 -39. doi: 10.3877/cma.j.issn.2095-2007.2023.01.007

综述

血脂异常与原发性开角型青光眼发病相关性的研究进展
李茹月, 庞睿奇, 王宁利()   
  1. 100730 首都医科大学附属北京同仁医院2020级硕士研究生
    100730 首都医科大学附属北京同仁医院2021级博士研究生
    100730 首都医科大学附属北京同仁医院北京同仁眼科中心 北京市眼科研究所 北京市眼科学与视觉科学重点实验室
  • 收稿日期:2022-01-27 出版日期:2023-02-28
  • 通信作者: 王宁利
  • 基金资助:
    国家自然科学基金项目(81730027)

Research progress of dyslipidemia in the pathogenesis of primary open angle glaucoma

Ruyue Li, Ruiqi Pang, Ningli Wang()   

  1. Master′s degree 2020, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Doctoral degree 2021, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Vision Sciences, Beijing 100730, China
  • Received:2022-01-27 Published:2023-02-28
  • Corresponding author: Ningli Wang
引用本文:

李茹月, 庞睿奇, 王宁利. 血脂异常与原发性开角型青光眼发病相关性的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(01): 35-39.

Ruyue Li, Ruiqi Pang, Ningli Wang. Research progress of dyslipidemia in the pathogenesis of primary open angle glaucoma[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(01): 35-39.

原发性开角型青光眼是最常见的青光眼类型。近年来,血脂异常在原发性开角型青光眼发病中的作用引发了广泛关注。血脂异常可能通过眼压、血液循环、视网膜神经节细胞、脂溶性维生素水平以及肠道菌群等多种途径影响原发性开角型青光眼的发生。本文中笔者就血脂异常与原发性开角型青光眼发病相关性的研究进展及其可能的发生机制进行综述。

Primary open angle glaucoma (POAG) is the most common type of glaucoma. Recently, the role of dyslipidemia in the incidence of POAG has caused wide attention, which may influence the occurrence of POAG by intraocular pressure, blood circulation, retinal ganglion cells, lipid-soluble vitamin levels and gut microbiota. The research progress and possible mechanism of dyslipidemia and POAG were reviewed in this paper.

表1 降脂药物与POAG相关性汇总
第一作者 发表年份 降脂药物类型 青光眼类型 主要结果
McGwin等[27] 2004 他汀类降脂药物-非他汀类降脂药物 POAG 因任何原因长期口服他汀类药物者患POAG的风险降低,服药时间超过23个月者效果尤其明显。非他汀类降胆固醇药物降低POAG风险仅限于使用时间少于12个月的患者。他汀类和非他汀类药物联合使用时,POAG发生风险最低
Marcus等[7] 2012 他汀类降脂药物 POAG 他汀类药物的使用可能对不依赖眼压升高型青光眼的发展具有保护作用
Stein等[28] 2012 他汀类降脂药物-非他汀类降脂药物 POAG 服用他汀类药物治疗高脂血症的患者发生POAG、从可疑青光眼进展为POAG以及需要青光眼治疗相关药物的风险降低,而进展期POAG患者并未减少手术需求。服用他汀类药物的时间越长,保护作用越大。
Khawaja等[29] 2014 他汀类降脂药物 眼压 调整混杂因素后,他汀类药物的使用与较低的眼压显著相关。药物类型、使用时间、既往用药史等均与POAG的发生与发展无显著相关。
Chen等[30] 2015 他汀类降脂药物 POAG 使用较高剂量他汀类药物(>120 DDD/年)会增加POAG风险
McCann等[23] 2016 他汀类降脂药物 青光眼 短期使用他汀类药物(<2年)使青光眼发病率降低了4%
Talwar等[14] 2017 他汀类降脂药物 POAG POAG发生风险降低的程度与每日摄入的他汀类药物剂量无关。在调整了基线LDL-C水平和其他混杂因素后,每增加1个月他汀类药物的使用,POAG发病风险降低1%;连续用药2年者发病风险降低21%
[1]
中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2019概要[J]. 中国循环杂志202035(9):833-854.
[2]
Wang S, Xu L, Jonas JB, et al. Dyslipidemia and eye diseases in the adult Chinese population: the Beijing eye study[J]. PLoS One, 2012, 7(3): e26871.
[3]
Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management[J]. Eur Heart J, 2011, 32(11): 1345-1361.
[4]
Wang S, Bao X. Hyperlipidemia, blood lipid level, and the risk of glaucoma: a meta-analysis[J]. Invest Ophthalmol Vis Sci, 2019, 60(4): 1028-1043.
[5]
Kim YH, Jung SW, Nam GE, et al. High intraocular pressure is associated with cardiometabolic risk factors in South Korean men: Korean National Health and Nutrition Examination Survey, 2008—2010[J]. Eye (Lond), 2014, 28(6): 672-679.
[6]
中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版)[J]. 中华全科医师杂志201716(1): 15-35.
[7]
Marcus MW, Müskens RP, Ramdas WD, et al. Cholesterol-lowering drugs and incident open-angle glaucoma: a population-based cohort study[J]. PLoS One, 2012, 7(1): e29724.
[8]
Pertl L, Mossböck G, Wedrich A, et al. Triglycerides and open angle glaucoma-a meta-analysis with meta-regression[J]. Sci Rep, 2017, 7(1): E7829.
[9]
Kim HA, Han K, Lee YA, et al. Differential association of metabolic risk factors with open angle glaucoma according to obesity in a korean population[J]. Sci Rep, 2016, 6: 38283.
[10]
Zhang Y, Zhang Q, Thomas R, et al. Association of hyper-triglyceridemia and incident glaucoma in a rural Chinese population: The Handan Eye Study[J]. Transl Vis Sci Technol, 2021, 10(8): 25.
[11]
Lee SH, Kim GA, Lee W, et al. Vascular and metabolic comorbidities in open-angle glaucoma with low and high-teen intraocular pressure: a cross-sectional study from South Korea[J]. Acta Ophthalmol, 2017, 95(7): e564-e574.
[12]
PavljaseviĉS, Asĉeriĉ M. Primary open-angle glaucoma and serum lipids[J]. Bosn J Basic Med Sci, 2009, 9(1): 85-88.
[13]
Ko F, Boland MV, Gupta P, et al. Diabetes, triglyceride levels, and other risk factors for glaucoma in the national health and nutrition examination survey 2005—2008[J]. Invest Ophthalmol Vis Sci, 2016, 1;57(4): 2152-2157.
[14]
Talwar N, Musch DC, Stein JD. Association of daily dosage and type of statin agent with risk of open-angle glaucoma[J]. JAMA Ophthalmol, 2017, 135(3): 263-267.
[15]
Kim MJ, Kim MJ, Kim HS, et al. Risk factors for open-angle glaucoma with normal baseline intraocular pressure in a young population: the Korea National Health and Nutrition Examination Survey[J]. Clin Exp Ophthalmol, 2014, 42(9): 825-832.
[16]
Lin HC, Chien CW, Hu CC, et al. Comparison of comorbid conditions between open-angle glaucoma patients and a control cohort: a case-control study[J]. Ophthalmology, 2010, 117(11): 2088-2095.
[17]
Newman-Casey PA, Talwar N, Nan B, et al. The relationship between components of metabolic syndrome and open-angle glaucoma[J]. Ophthalmology, 2011, 118(7): 1318-1326.
[18]
Xu M, Li S, Zhu J, et al. Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization[J]. BMC Ophthalmol, 2020, 20(1): 390.
[19]
dos-Santos MG, Makk S, Berghold A, et al. Intraocular pressure difference in Goldmann applanation tonometry versus Perkins hand-held applanation tonometry in overweight patients[J]. Ophthalmology, 1998, 105(12): 2260-2263.
[20]
Kim M, Jeoung JW, Park KH, et al. Metabolic syndrome as a risk factor in normal-tension glaucoma[J]. Acta Ophthalmol, 2014, 92(8): e637-e643.
[21]
韩菲,殷玲,路国涛,等. 高密度脂蛋白与代谢综合征的关系[J]. 医学综述202026(2):356-360,365.
[22]
Hwang IC, Lee YJ, Bae JH. A meta-analysis of glaucoma risk in hyperlipidemic individuals: a critical problem in design[J]. Invest Ophthalmol Vis Sci, 2016, 57(14): 6339-6340.
[23]
McCann P, Hogg RE, Fallis R, et al. The effect of statins on intraocular pressure and on the incidence and progression of glaucoma: a systematic review and meta-analysis[J]. Invest Ophthalmol Vis Sci, 2016, 57(6): 2729-2748.
[24]
Kim MJ, Park KH, Kim CY, et al. The distribution of intraocular pressure and associated systemic factors in a Korean population: the Korea National Health and Nutrition Examination Survey[J]. Acta Ophthalmol, 2014, 92(7): e507-e513.
[25]
Zheng YCheung CY, Wong TY, et al. Influence of height, weight, and body mass index on optic disc parameters[J]. Invest Ophthalmol Vis Sci, 2010, 51(6): 2998-3002.
[26]
Xu L, Wang YX, Wang S, et al. Neuroretinal rim area and body mass index[J]. PLoS One, 2012, 7(1): e30104.
[27]
McGwin G, McNeal S, Owsley C, et al. Statins and other cholesterol-lowering medications and the presence of glaucoma[J]. Arch Ophthalmol, 2004, 122(6): 822-826.
[28]
Stein JD, Newman-Casey PA, Talwar N, et al. The relationship between statin use and open-angle glaucoma[J]. Ophthalmology, 2012, 119(10): 2074-2081.
[29]
Khawaja AP, Chan MP, Broadway DC, et al. Systemic medication and intraocular pressure in a British population: the EPIC-Norfolk Eye Study[J]. Ophthalmology, 2014, 121(8): 1501-1507.
[30]
Chen HY, Hsu SY, Chang YC, et al. Association between statin use and open-angle glaucoma in hyperlipidemia patients: A Taiwanese Population-based Case-control Study[J]. Medicine (Baltimore), 2015, 94(45): e2018.
[31]
Song J, Deng PF, Stinnett SS, et al. Effects of cholesterol-lowering statins on the aqueous humor outflow pathway[J]. Invest Ophthalmol Vis Sci, 2005, 46(7): 2424-2432.
[32]
Jia LY, Gong B, Pang CP, et al. Correction of the disease phenotype of myocilin-causing glaucoma by a natural osmolyte[J]. Invest Ophthalmol Vis Sci, 2009, 50(8): 3743-3749.
[33]
乐世俊,王文晓,陶慧娟,等. 肠道菌群-TMA-TMAO代谢途径与心血管疾病的研究进展[J]. 中华心血管病杂志202048(2):159-163.
[34]
Skrzypecki J, Izdebska J, Kamińska A, et al. Glaucoma patients have an increased level of trimethylamine, a toxic product of gut bacteria, in the aqueous humor: a pilot study[J]. Int Ophthalmol, 2021, 41(1): 341-347.
[35]
Yoo W, Zieba JK, Foegeding NJ, et al. High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide[J]. Science, 2021, 373(6556): 813-818.
[36]
Bulpitt CJ, Hodes C, Everitt MG. Intraocular pressure and systemic blood pressure in the elderly[J]. Br J Ophthalmol, 1975, 59(12): 717-720.
[37]
Shiose Y. The aging effect on intraocular pressure in an apparently normal population[J]. Arch Ophthalmol, 1984, 102(6): 883-887.
[38]
Fu J, Bonder MJ, Cenit MC, et al. The gut microbiome contributes to a substantial proportion of the variation in blood lipids[J]. Circ Res, 2015, 117(9): 817-24.
[39]
Mancia G, Bousquet P, Elghozi JL, et al. The sympathetic nervous system and the metabolic syndrome[J]. J Hypertens, 2007, 25(5): 909-920.
[40]
MacDougald OA, Burant CF. Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter[J]. Proc Natl Acad Sci USA, 2005, 102(31): 10759-10760.
[41]
常田,杨雪丽,王鹏旭,等. 肠道菌群与糖尿病眼部并发症关系的研究进展[J]. 中华糖尿病杂志202012(7):551-554.
[42]
Andriessen EM, Wilson AM, Mawambo G, et al. Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization[J]. EMBO Mol Med, 2016, 8(12): 1366-1379.
[43]
Deschênes MC, Descovich D, Moreau M, et al. Postmenopausal hormone therapy increases retinal blood flow and protects the retinal nerve fiber layer[J]. Invest Ophthalmol Vis Sci, 2010, 51(5): 2587-2600.
[44]
Rowan S, Taylor A. Gut microbiota modify risk for dietary glycemia-induced age-related macular degeneration[J]. Gut Microbes, 2018, 9(5): 452-457.
[45]
Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans[J]. N Engl J Med. 1996, 334(5): 292-295.
[46]
López-Riquelme N, Villalba C, Tormo C, et al. Endothelin-1 levels and biomarkers of oxidative stress in glaucoma patients[J]. Int Ophthalmol, 2015, 35(4): 527-532.
[47]
Wang SY, Singh K, Lin SC. Glaucoma and vitamins A, C, and E supplement intake and serum levels in a population-based sample of the United States[J]. Eye (Lond), 2013, 27(4): 487-494.
[48]
Zhang F, Wang S, Signore AP, et al. Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia[J]. Stroke, 2007, 38(8): 2329-2336.
[49]
Saccà SC, Gandolfi S, Bagnis A, et al. The Outflow Pathway: A Tissue With Morphological and Functional Unity[J]. J Cell Physiol, 2016, 231(9): 1876-93.
[50]
田佳鑫,曹凯,石砚,等. 原发性开角型青光眼全身危险因素及眼体同治的系统回顾和Meta分析[J]. 中华眼科医学杂志(电子版)20199(5):281-291.
[51]
Kim HJ, Min KB, Min JY. Neuropeptide Y gene-by-psychosocial stress interaction effect is associated with obesity in a Korean population[J]. Psychoneuroendocrinology, 2016, 69: 10-15.
[52]
Santos-Carvalho A, Elvas F, Alvaro AR, et al. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate[J]. Cell Death Dis, 2013, 4(5): e636.
[53]
Kishida K, Naka KI. Amino acids and the spikes from the retinal ganglion cells[J]. Science, 1967, 156(3775): 648-650.
[54]
Cao X, Guo Y, Wang Y, et al. Effects of high-fat diet and Apoe deficiency on retinal structure and function in mice[J]. Sci Rep, 2020, 10(1): 18601.
[55]
Ramdas WD, Schouten JSAG, Webers CAB. The effect of vitamins on glaucoma: a systematic review and meta-analysis[J]. Nutrients, 2018, 10(3): 359.
[56]
Pang R, Feng S, Cao K, et al. Association of serum retinol concentration with normal-tension glaucoma[J]. Eye (Lond), 2022, 36(9): 1820-1825.
[1] 李丹阳, 李满祥. 肠道菌群失调在肺动脉高压发病中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 432-434.
[2] 何吉鑫, 杨燕妮, 王继伟, 李建国, 谢铭. 肠道菌群及肠道代谢产物参与慢性便秘发生机制的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 495-499.
[3] 乔小梅, 孔凯丽, 方敬爱, 张晓东. "肠-皮肤轴"与尿毒症皮肤病变的关系研究进展[J]. 中华肾病研究电子杂志, 2023, 12(05): 291-294.
[4] 李娜, 朱国贞. 肠道菌群及其代谢产物在急性肾损伤中的作用研究进展[J]. 中华肾病研究电子杂志, 2023, 12(04): 215-219.
[5] 邓荣珍, 罗宇珍, 赵若蓓, 邓杨, 廖蕴华, 潘玲. 血脂与IgA肾病患者肾脏预后的相关性研究[J]. 中华肾病研究电子杂志, 2023, 12(01): 13-19.
[6] 冷玥祺, 廖衍沣, 武歆纯, 李美瑶, 石逸雯, 王晋豪, 杨嘉瑞, 李学民. 环境因素对眼部生理与病理影响的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(02): 109-113.
[7] 王宁, 刘彦哲, 吴紫莺, 曾超, 雷光华, 沙婷婷, 王伊伦. 基于孟德尔随机化研究探讨肠道菌群与肌少症表型的因果关联[J]. 中华老年骨科与康复电子杂志, 2023, 09(06): 333-342.
[8] 屈霄, 王靓, 陆萍, 何斌, 孙敏. 外周血炎症因子及肠道菌群特征与活动性溃疡性结肠炎患者病情的相关性分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 466-470.
[9] 孙晗, 武侠. 成人肠易激综合征患者肠道菌群特征与不同分型患者生活质量和精神症状的相关性[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 461-465.
[10] 廖想, 李爽, 曾瑶. 2012-2021年粪菌移植研究的趋势及热点分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(02): 93-99.
[11] 张大涯, 陈世锔, 陈润祥, 张晓冬, 李达, 白飞虎. 肠道微生物群对代谢相关脂肪性肝病发展的影响[J]. 中华临床医师杂志(电子版), 2023, 17(07): 828-833.
[12] 韩家超, 王飞飞, 柳子宁, 胡冀陶, 孟泽松, 雒月云, 王贵英. 二甲双胍的作用机制研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(03): 349-355.
[13] 杜青瑶, 曹颖雯, 林健雄, 郝润, 王静敏, 徐锐权, 寇晓霞. 肠道菌群促进诺如病毒感染的机制[J]. 中华临床实验室管理电子杂志, 2023, 11(04): 241-244,255.
[14] 刘艳, 唐神结. 肠道菌群与抗结核药及其所致肝损伤的相关性研究进展[J]. 中华诊断学电子杂志, 2023, 11(02): 82-86.
[15] 金泽平, 董晶, 柳云鹏, 汪阳. 菌群-肠道-脑轴与缺血性卒中危险因素关系的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 510-517.
阅读次数
全文


摘要