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中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (01) : 35 -39. doi: 10.3877/cma.j.issn.2095-2007.2023.01.007

综述

血脂异常与原发性开角型青光眼发病相关性的研究进展
李茹月, 庞睿奇, 王宁利()   
  1. 100730 首都医科大学附属北京同仁医院2020级硕士研究生
    100730 首都医科大学附属北京同仁医院2021级博士研究生
    100730 首都医科大学附属北京同仁医院北京同仁眼科中心 北京市眼科研究所 北京市眼科学与视觉科学重点实验室
  • 收稿日期:2022-01-27 出版日期:2023-02-28
  • 通信作者: 王宁利
  • 基金资助:
    国家自然科学基金项目(81730027)

Research progress of dyslipidemia in the pathogenesis of primary open angle glaucoma

Ruyue Li, Ruiqi Pang, Ningli Wang()   

  1. Master′s degree 2020, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Doctoral degree 2021, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Vision Sciences, Beijing 100730, China
  • Received:2022-01-27 Published:2023-02-28
  • Corresponding author: Ningli Wang
引用本文:

李茹月, 庞睿奇, 王宁利. 血脂异常与原发性开角型青光眼发病相关性的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2023, 13(01): 35-39.

Ruyue Li, Ruiqi Pang, Ningli Wang. Research progress of dyslipidemia in the pathogenesis of primary open angle glaucoma[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(01): 35-39.

原发性开角型青光眼是最常见的青光眼类型。近年来,血脂异常在原发性开角型青光眼发病中的作用引发了广泛关注。血脂异常可能通过眼压、血液循环、视网膜神经节细胞、脂溶性维生素水平以及肠道菌群等多种途径影响原发性开角型青光眼的发生。本文中笔者就血脂异常与原发性开角型青光眼发病相关性的研究进展及其可能的发生机制进行综述。

Primary open angle glaucoma (POAG) is the most common type of glaucoma. Recently, the role of dyslipidemia in the incidence of POAG has caused wide attention, which may influence the occurrence of POAG by intraocular pressure, blood circulation, retinal ganglion cells, lipid-soluble vitamin levels and gut microbiota. The research progress and possible mechanism of dyslipidemia and POAG were reviewed in this paper.

表1 降脂药物与POAG相关性汇总
第一作者 发表年份 降脂药物类型 青光眼类型 主要结果
McGwin等[27] 2004 他汀类降脂药物-非他汀类降脂药物 POAG 因任何原因长期口服他汀类药物者患POAG的风险降低,服药时间超过23个月者效果尤其明显。非他汀类降胆固醇药物降低POAG风险仅限于使用时间少于12个月的患者。他汀类和非他汀类药物联合使用时,POAG发生风险最低
Marcus等[7] 2012 他汀类降脂药物 POAG 他汀类药物的使用可能对不依赖眼压升高型青光眼的发展具有保护作用
Stein等[28] 2012 他汀类降脂药物-非他汀类降脂药物 POAG 服用他汀类药物治疗高脂血症的患者发生POAG、从可疑青光眼进展为POAG以及需要青光眼治疗相关药物的风险降低,而进展期POAG患者并未减少手术需求。服用他汀类药物的时间越长,保护作用越大。
Khawaja等[29] 2014 他汀类降脂药物 眼压 调整混杂因素后,他汀类药物的使用与较低的眼压显著相关。药物类型、使用时间、既往用药史等均与POAG的发生与发展无显著相关。
Chen等[30] 2015 他汀类降脂药物 POAG 使用较高剂量他汀类药物(>120 DDD/年)会增加POAG风险
McCann等[23] 2016 他汀类降脂药物 青光眼 短期使用他汀类药物(<2年)使青光眼发病率降低了4%
Talwar等[14] 2017 他汀类降脂药物 POAG POAG发生风险降低的程度与每日摄入的他汀类药物剂量无关。在调整了基线LDL-C水平和其他混杂因素后,每增加1个月他汀类药物的使用,POAG发病风险降低1%;连续用药2年者发病风险降低21%
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