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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (02) : 120 -124. doi: 10.3877/cma.j.issn.2095-2007.2022.02.011

综述

血清淀粉样蛋白A在眼科疾病中作用机制的研究进展
刘晓娜1, 王伟1, 吴峰1, 宋桃1, 郑美琴2,†(), 郑来宝3   
  1. 1. 250200　济南明水眼科医院检验科
    2. 325000　温州医科大学附属眼视光医院检验病理中心
    3. 325002　温州医科大学检验医学院卫生检验与检验系　检验医学教育部重点实验室　温州市环境卫生微生物检验检验重点实验室
  • 收稿日期:2021-09-13 出版日期:2022-04-28
  • 通信作者: 郑美琴
  • 基金资助:
    浙江省自然科学基金基础公益研究计划项目(LQ21H200008)

Research progress on the mechanism of serum amyloid A in ophthalmic diseases

Xiaona Liu1, Wei Wang1, Feng Wu1, Tao Song1, Meiqin Zheng2,†(), Laibao Zheng3   

  1. 1. Clinical Laboratory, Mesee Eye Hospital, Jinan 250200, China
    2. Laboratory Pathology Centre, Zhejiang Eye Hospital, Wenzhou 325000, China
    3. Department of Health Inspection and Testing, College of Laboratory Medicine, Wenzhou Medical University, Key Laboratory of Laboratory Medicine of Ministry of Education, Wenzhou Key Laboratory of Microbiological Inspection of Environmental Health, Wenzhou 325002, China
  • Received:2021-09-13 Published:2022-04-28
  • Corresponding author: Meiqin Zheng
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引用本文：

刘晓娜, 王伟, 吴峰, 宋桃, 郑美琴, 郑来宝. 血清淀粉样蛋白A在眼科疾病中作用机制的研究进展[J]. 中华眼科医学杂志(电子版), 2022, 12(02): 120-124.

Xiaona Liu, Wei Wang, Feng Wu, Tao Song, Meiqin Zheng, Laibao Zheng. Research progress on the mechanism of serum amyloid A in ophthalmic diseases[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(02): 120-124.

血清淀粉样蛋白A(SAA)是一种非特异性急性时相反应蛋白。健康人血液中一般含量很低，在机体急性炎症时期其血浆浓度可升高1000多倍，随着炎症好转又能迅速恢复至正常水平。SAA水平的提高是由感染、创伤、炎症反应及癌症对宿主组织造成损伤引起的。当机体发生小范围炎症时，其水平也会明显高于正常值。因此，可以作为敏感地反映炎症的实验室标志物。联合检测血常规、C反应蛋白及SAA，可为全身炎症性疾病早期细菌与病毒感染的鉴别诊断提供有力的诊断依据。SAA在局部炎症性疾病中作用机制的报道较少。本文中笔者就SAA在眼科疾病中作用机制的研究进展进行综述。

关键词: 血清淀粉样蛋白A, 眼科疾病, 感染性角膜炎

Serum amyloid A (SAA) is a nonspecific acute reactive protein. There is usually a very low level in the blood of healthy people. During the period of acute inflammation for patients, the plasma concentration of SAA could increase by more than 1000 times. The increase of SAA levels is resulted from the physical damage for cells, including infection, trauma, inflammation and cancer. When the body occurs a small area of inflammation stimulation, the SAA level will be significantly higher than the normal range. Therefore, SAA has become the most sensitive marker reflecting inflammatory infection at present. SAA combined with detection of blood routine examination and C-reactive protein had been widely used in systemic inflammatory diseases in the recent years, which could provide a strong diagnostic basis for the differential diagnosis of bacterial and viral infection in the early stage. However, the advances on the clinical application of SAA in local inflammatory diseases is rarely reported. Thus, the clinical application of SAA in ophthalmology were reviewed.

Key words: Serum amyloid A, Ophthalmic diseases, Infectious keratitis
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