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中华眼科医学杂志(电子版) ›› 2021, Vol. 11 ›› Issue (06) : 370 -374. doi: 10.3877/cma.j.issn.2095-2007.2021.06.009

综述

虹膜角膜内皮综合征病因与病生理机制的研究进展
张嘉昕1, 洪晶2,()   
  1. 1. 100191 北京大学第三医院2016级八年制研究生
    2. 100191 北京大学第三医院眼科
  • 收稿日期:2021-06-05 出版日期:2021-12-28
  • 通信作者: 洪晶
  • 基金资助:
    国家自然科学基金资助项目(81970768)

Advances on the etiology and pathogenesis of iridocorneal endothelial syndrome

Jiaxin Zhang1, Jing Hong2,()   

  1. 1. Eight-year program 2016, Peking University 3Hospital, Beijing 100191, China
    2. Ophthalmology Department, Peking University 3Hospital, Beijing 100191, China
  • Received:2021-06-05 Published:2021-12-28
  • Corresponding author: Jing Hong
引用本文:

张嘉昕, 洪晶. 虹膜角膜内皮综合征病因与病生理机制的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2021, 11(06): 370-374.

Jiaxin Zhang, Jing Hong. Advances on the etiology and pathogenesis of iridocorneal endothelial syndrome[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(06): 370-374.

虹膜角膜内皮(ICE)综合征是一组眼科疾病的总称,包含Chandler综合征(CS)、虹膜色素痣综合征(CRS)和进行性或实质性虹膜萎缩(PIA/EIA)三个亚型,以角膜内皮细胞异常增殖并向虹膜表面迁移为特点,病情缓慢进展且不可治愈。关于本病,目前认为可能的病因是病毒感染,异常内皮膜的形成与收缩则是目前广泛认可的病生理过程。本文中笔者就此病病因与病生理机制的研究现状进行综述。

Iris corneal endothelial (ICE) syndrome is the general name of a group of ophthalmic diseases, including Chandler syndrome (CS), iris nevus syndrome (CRS) and progressive or substantial iris atrophy (PIA / EIA). ICE characterized by abnormal proliferation of corneal endothelial cells and migration to the iris surface. ICE progresses slowly and is incurable. It has been demonstrated that the possible etiology of ICE has been related with viral infection, and the formation and contraction of abnormal endothelial membrane has a widely recognized pathophysiological process. In this paper, the research status of the etiology and pathophysiological mechanism of ICE were reviewed.

图1 ICE细胞模式图
图2 正常角膜内皮细胞模式图
图3 角膜后弹力层异常结构模式图
表1 ICE综合征的病毒病因学研究历史
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