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中华眼科医学杂志(电子版) ›› 2021, Vol. 11 ›› Issue (03) : 188 -192. doi: 10.3877/cma.j.issn.2095-2007.2021.03.011

综述

青光眼滤过术后瘢痕化机制与抗瘢痕化治疗的研究进展
马铭绅1, 申颖2, 李文萱3, 关文英2, 康欣4, 赵海霞2,()   
  1. 1. 010050 呼和浩特,内蒙古医科大学2019级硕士研究生;010050 呼和浩特,内蒙古医科大学附属医院眼科
    2. 010050 呼和浩特,内蒙古医科大学2019级硕士研究生
    3. 010050 呼和浩特,内蒙古医科大学附属医院眼科
    4. 100853 北京,中国人民解放军总医院眼科学部
  • 收稿日期:2020-10-30 出版日期:2021-06-28
  • 通信作者: 赵海霞
  • 基金资助:
    内蒙古自治区自然科学基金项目(2019MS08142)

Advances on the mechanism of glaucoma filtration surgery scarring and anti-scarring treatment

Mingshen Ma1, Ying Shen2, Wenxuan Li3, Wenying Guan2, Xin Kang4, Haixia Zhao2,()   

  1. 1. Master′s degree 2019, Inner Mongolia Medical University, Hohhot 010050, China; Department of Ophthalmology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
    2. Master′s degree 2019, Inner Mongolia Medical University, Hohhot 010050, China
    3. Department of Ophthalmology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
    4. Department of Ophthalmology, Chinese People′s Liberation Army General Hospital, Beijing 100853, China
  • Received:2020-10-30 Published:2021-06-28
  • Corresponding author: Haixia Zhao
引用本文:

马铭绅, 申颖, 李文萱, 关文英, 康欣, 赵海霞. 青光眼滤过术后瘢痕化机制与抗瘢痕化治疗的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2021, 11(03): 188-192.

Mingshen Ma, Ying Shen, Wenxuan Li, Wenying Guan, Xin Kang, Haixia Zhao. Advances on the mechanism of glaucoma filtration surgery scarring and anti-scarring treatment[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(03): 188-192.

青光眼已成为全球范围内不可逆致盲的首要因素。眼压的病理性升高是青光眼最为危险的因素之一,由此可导致特征性视神经损伤。在过去的50年里,青光眼滤过术作为降低青光眼眼压的主要治疗手段,但其术后常因滤过泡瘢痕化,滤过通道房水流出受阻,导致手术失败。因此,明确青光眼滤过术后抗瘢痕化的机制对青光眼的治疗至关重要。本文中笔者就国内外针对瘢痕化形成的信号通路与当前抗瘢痕化治疗方法的研究进行综述,旨在为提高手术的成功率和临床新药开发提供新思路。

Glaucoma has become the leading cause of irreversible blindness in the world. The pathological increase in intraocular pressure is one of the most dangerous factor leading glaucoma, which would cause characteristic optic nerve damage. In the past 50 years, glaucoma filtering surgery has been the primary treatment for reducing glaucoma intraocular pressure. Glaucoma filtering surgery often scares the filtering bleb after the operation, which obstructing the outflow of aqueous humor through the filtering channel, causing the function to fail. To clarify, the anti-scarring mechanism after glaucoma filtering operation is essential for the treatment of glaucoma. Therefore, the research on scar formation signal pathways worldwide and the current anti-scarring treatment methods were reviewed in this paper, aiming to provide new ideas for improving surgery outcome and the development of new clinical drugs.

图1 光学显微镜下苏木精-伊红染色兔行青光眼滤过术后的组织成像 可见滤过区成纤维细胞浸润,结缔组织较为紧密(箭头所指处,×100)
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