干眼对生活质量影响的相关研究进展

doi:10.3877/cma.j.issn.2095-2007.2020.01.009

干眼是一种日益严重的公共卫生问题，临床常见的干眼引起的眼部不适包括眼部干涩、视疲劳、眼异物感、烧灼感及畏光等，进一步可导致视觉损害和对比敏感度降低。这些不适很大程度上影响了干眼患者的身体功能、社会功能、心理功能、日常活动及工作生产力等情况。但干眼的视觉障碍对患者生活质量的影响不易量化，本文中笔者结合现有相关文献，对干眼视觉障碍的评估方法及其对生活质量的影响进行综述。旨在为临床工作提供指导。

关键词: 干眼, 生活质量, 视觉障碍, 测量方法

Dry eye disease is an increasingly serious public health problem. The common eye discomfort caused by dry eye disease in clinic includes eye dryness, visual fatigue, foreign body sensation, burning sensation and photophobia, which further leads to visual damage and reduces contrast sensitivity. These discomforts greatly affected the quality of life, which including physical function, social function, psychological function, daily activities and work productivity. The effect of visual disturbance on patients′ quality of life with dry eye disease was difficult or impossible to achieve for certain. In this review, we summarize the evaluation method of visual impairment and the impact on quality of life from dry eye disease by reviewing the published literature, which aims to provide the reference for clinical practice.

Key words: Dry eye disease, Quality of life, Visual impairment, Measurement methods

[1]	Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS Ⅱ definition and classification report[J]. Ocul Surf, 2017, 15(3): 276-283.
[2]	Lin PY, Cheng CY, Hsu WM, et al. Association between symptoms and signs of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study[J]. Invest Ophthalmol Vis Sci, 2005, 46(5): 1593-1598.
[3]	Alshamrani AA, Almousa AS, Almulhim AA, et al. Prevalence and risk factors of dry eye symptoms in a Saudi Arabian population[J]. Middle East Afr J Ophthalmol, 2017, 24(2): 67-73.
[4]	Farrand KF, Fridman M, Stillman IO, et al. Prevalence of diagnosed dry eye disease in the United States among adults aged 18 years and older[J]. Am J Ophthalmol, 2017, 182(10): 90-98.
[5]	Ferrero A, Alassane S, Binquet C, et al. Dry eye disease in the elderly in a French population-based study (the Montrachet study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases): Prevalence and associated factors[J]. Ocul Surf, 2018, 16(1): 112-119.
[6]	Titiyal JS, Falera RC, Kaur M, et al. Prevalence and risk factors of dry eye disease in North India: Ocular surface disease index-based cross-sectional hospital study[J]. Indian J Ophthalmol, 2018, 66(2): 207-211.
[7]	Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS Ⅱ epidemiology report[J]. Ocul Surf, 2017, 15(3): 334-365.
[8]	Song P, Xia W, Wang M, et al. Variations of dry eye disease prevalence by age, sex and geographic characteristics in China: a systematic review and meta-analysis[J]. J Glob Health, 2018, 8(2): 20503.
[9]	Goto E, Yagi Y, Matsumoto Y, et al. Impaired functional visual acuity of dry eye patients[J]. Am J Ophthalmol, 2002, 133(2): 181-186.
[10]	Puell M, Benítez-del-Castillo J, Martínez-de-la-Casa J, et al. Contrast sensitivity and disability glare in patients with dry eye[J]. Acta Ophthalmol Scand, 2006, 84(4): 527-531.
[11]	Begley CG, Chalmers RL, Abetz L, et al. The Relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity[J]. Invest Ophthalmol Vis Sci, 2003, 44(11): 4753-4761.
[12]	Rajagopalan K, Abetz L, Mertzanis P, et al. Comparing the discriminative validity of two generic and one disease-specific health-related quality of life measures in a sample of patients with dry eye[J]. Value Health, 2005, 8(2): 168-174.
[13]	Tutt R, Bradley A, Begley C, et al. Optical and visual impact of tear break-up in human eyes[J]. Invest Ophthalmol Vis Sci, 2000, 41(13): 4117-4123.
[14]	Schiffman RM, Christianson MD, Jacobsen G, et al. Reliability and validity of the ocular surface disease index[J]. Arch Ophthalmol, 2000, 118(5): 615-621.
[15]	Li M, Gong L, Chapin WJ, et al. Assessment of vision-related quality of life in dry eye patients[J]. Invest Ophthalmol Vis Sci, 2012, 53(9): 5722-5727.
[16]	Chalmers RL, Begley CG, Caffery B. Validation of the 5-Item Dry Eye Questionnaire (DEQ-5): Discrimination across self-assessed severity and aqueous tear deficient dry eye diagnoses[J]. Contact Lens Anterior Eye, 2010, 33(2): 55-60.
[17]	Begley CG, Caffery B, Chalmers RL, et al. Use of the dry eye questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficient dry eye[J]. Cornea, 2002, 21(7): 664-670.
[18]	Bjerrum KB. Test and symptoms in keratoconjunctivitis sicca and their correlation[J]. Acta Ophthalmol Scand, 1996, 74(5): 436-441.
[19]	Abetz L, Rajagopalan K, Mertzanis P, et al. Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients[J]. Health Qual Life Outcomes, 2011, 9(1): 111.
[20]	Nichols KK, Mitchell GL, Zadnik K. Performance and repeatability of the NEI-VFQ-25 in patients with dry eye[J]. Cornea, 2002, 21(6): 578-583.
[21]	Le Q, Zhou X, Ge L, et al. Impact of dry eye syndrome on vision-related quality of life in a non-clinic-based general population[J]. BMC Ophthalmol, 2012, 12(1): 22.
[22]	Sakane Y, Yamaguchi M, Yokoi N, et al. Development and validation of the dry eye-related quality-of-life score questionnaire[J]. JAMA Ophthalmology, 2013, 131(10): 1331-1338.
[23]	Shiraishi A, Sakane Y. Assessment of Dry eye symptoms: current trends and issues of dry eye questionnaires in Japan[J]. Invest Ophthalmol Vis Sci, 2018, 59(14): DES23-DES28.
[24]	González-Pérez M, Susi R, Antona B, et al. The Computer-Vision Symptom Scale (CVSS17): development and initial validation[J]. Invest Ophthalmol Vis Sci, 2014, 55(7): 4504-4511.
[25]	Nilforoushan MR, Latkany RA, Speaker MG. Effect of artificial tears on visual acuity[J]. Am J Ophthalmol, 2005, 140(5): 830-835.
[26]	Ishida R, Kojima T, Dogru M, et al. The application of a new continuous functional visual acuity measurement system in dry eye syndromes[J]. Am J Ophthalmol, 2005, 139(2): 253-258.
[27]	Kaido M, Dogru M, Yamada M, et al. Functional visual acuity in Stevens-Johnson syndrome[J]. Am J Ophthalmol, 2006, 142(6): 917-922, e911.
[28]	Kaido M, Matsumoto Y, Shigeno Y, et al. Corneal fluorescein staining correlates with visual function in dry eye patients[J]. Invest Ophthalmol Vis Sci, 2011, 52(13): 9516-9522.
[29]	Kaido M, Toda I, Ishida R, et al. Age-related changes in functional visual acuity in healthy individuals[J]. Japan J Ophthalmol, 2011, 55(3): 183-189.
[30]	Hara S, Kojima T, Ishida R, et al. Evaluation of tear stability after surgery for conjunctivochalasis[J]. Optometry Vis Sci, 2011, 88(9): 1112-1118.
[31]	Kaido M, Matsutani T, Negishi K, et al. Aged drivers may experience decreased visual function while driving[J]. Asia Pacific J Ophthalmol, 2013, 2(3): 150-158.
[32]	Kaido M, Kawashima M, Yokoi N, et al. Advanced dry eye screening for visual display terminal workers using functional visual acuity measurement: the Moriguchi study[J]. Br J Ophthalmol, 2015, 99(11): 1488-1492.
[33]	Ridder WH, Tomlinson A, Huang JF, et al. Impaired visual performance in patients with dry eye[J]. Ocul Surf, 2011, 9(1): 42-55.
[34]	Rolando M, Iester M, Macri A, et al. Low spatial-contrast sensitivity in dry eyes[J]. Cornea, 1998, 17(4): 376-379.
[35]	Huang FC, Tseng SH, Shih MH, et al. Effect of artificial tears on corneal surface regularity, contrast sensitivity, and glare disability in dry eyes[J]. Ophthalmology, 2002, 109(10): 1934-1940.
[36]	Liu H, Thibos L, Begley CG, et al. Measurement of the time course of optical quality and visual deterioration during tear break-up[J]. Invest Ophthalmol Vis Sci, 2010, 51(6): 3318-3326.
[37]	Montes-Mico R, Caliz A, Alio JL. Wavefront analysis of higher order aberrations in dry eye patients[J]. J Refract Surg, 2004, 20(3): 243-247.
[38]	Koh S, Maeda N, Hirohara Y, et al. Serial Measurements of higher-order aberrations after blinking in patients with dry eye[J]. Invest Ophthalmol Vis Sci, 2008, 49(1): 133-138.
[39]	Denoyer A, Rabut G, Baudouin C. Tear film aberration dynamics and vision-related quality of life in patients with dry eye disease[J]. Ophthalmology, 2012, 119(9): 1811-1818.
[40]	Habay T, Majzoub S, Perrault O, et al. Ĕvaluation objective de l'impact fonctionnel de la sévérité de la sécheresse oculaire sur la qualité de vision par aberrométrie double passage[J]. J Franais d'Ophtalmologie, 2014, 37(3): 188-194.
[41]	Koh S, Maeda N, Ikeda C, et al. Ocular forward light scattering and corneal backward light scattering in patients with dry eye[J]. Invest Ophthalmol Vis Sci, 2014, 55(10): 6601-6606.
[42]	Han SB, Yang HK, Hyon JY, et al. Association of dry eye disease with psychiatric or neurological disorders in elderly patients[J]. Clin Interv Aging, 2017, 12: 785-792.
[43]	Zheng Y, Wu X, Lin X, et al. The prevalence of depression and depressive symptoms among eye disease patients: a systematic review and meta-analysis[J]. Sci Rep, 2017, 7: 46453.
[44]	Wan KH, Chen LJ, Young AL. Depression and anxiety in dry eye disease: a systematic review and meta-analysis[J]. Eye (Lond), 2016, 30(12): 1558-1567.
[45]	Labbe A, Wang YX, Jie Y, et al. Dry eye disease, dry eye symptoms and depression: the Beijing Eye Study[J]. Br J Ophthalmol, 2013, 97(11): 1399-1403.
[46]	Kim KW, Han SB, Han ER, et al. Association between depression and dry eye disease in an elderly population[J]. Invest Ophthalmol Vis Sci, 2011, 52(11): 7954-7958.
[47]	Miljanovic B, Trivedi KA, Dana MR, et al. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women[J]. Am J Clin Nutr, 2005, 82(4): 887-893.
[48]	Lutgendorf SK, Garand L, Buckwalter KC, et al. Life stress, mood disturbance, and elevated interleukin-6 in healthy older women[J]. J Gerontol A Biol Sci Med Sci, 1999, 54(9): M434-M439.
[49]	Liyue H, Chiang PP, Sung SC, et al. Dry eye-related visual blurring and irritative symptoms and their association with depression and anxiety in eye clinic patients[J]. Curr Eye Res, 2016, 41(5): 590-599.
[50]	Li M, Gong L, Chapin WJ, et al. Assessment of vision-related quality of life in dry eye patients[J]. Invest Ophthalmol Vis Sci, 2012, 53(9): 5722-5727.
[51]	Wilson K, Mottram P. A comparison of side effects of selective serotonin reuptake inhibitors and tricyclic antidepressants in older depressed patients: a meta-analysis[J]. Int J Geriatr Psychiatry, 2004, 19(8): 754-762.
[52]	Ghaffariyeh A, Chamacham T. Tricyclic antidepressants: potential therapeutic alternatives for treatment of dry eye symptoms after LASIK[J]. J Refract Surg, 2008, 24(8): 770-771.
[53]	Mrugacz M, Ostrowska L, Lazarczyk-Kirejczyk J, et al. Dry eye disease in patients treated with antidepressants[J]. Klin Oczna, 2013, 115(2): 111-114.
[54]	Kocer E, Kocer A, Ozsutcu M, et al. Dry eye related to commonly used new antidepressants[J]. J Clin Psycho-pharmacol, 2015, 35(4): 411-413.
[55]	Ayaki M, Tsubota K, Kawashima M, et al. Sleep disorders are a prevalent and serious comorbidity in dry eye[J]. Invest Ophthalmol Vis Sci, 2018, 59(14): des143-des150.
[56]	Ayaki M, Kawashima M, Negishi K, et al. Sleep and mood disorders in women with dry eye disease[J]. Sci Rep, 2016, 6: 35276.
[57]	Kawashima M, Uchino M, Yokoi N, et al. The association of sleep quality with dry eye disease: the Osaka study[J]. Clin Ophthalmol, 2016, 10: 1015-1021.
[58]	Lee W, Lim SS, Won JU, et al. The association between sleep duration and dry eye syndrome among Korean adults[J]. Sleep Med, 2015, 16(11): 1327-1331.
[59]	Ong ES, Alghamdi YA, Levitt RC, et al. Longitudinal examination of frequency of and risk factors for severe dry eye symptoms in US veterans[J]. JAMA Ophthalmol, 2017, 135(2): 116-123.
[60]	Galor A, Seiden BE, Park JJ, et al. The association of dry eye symptom severity and comorbid insomnia in US veterans[J]. Eye Contact Lens, 2018, 44(1): s118-s124.
[61]	Gangwisch JE. Epidemiological evidence for the links between sleep, circadian rhythms and metabolism[J]. Obes Rev, 2009, 10(2): 37-45.
[62]	Doi Y, Minowa M, Tango T. Impact and correlates of poor sleep quality in Japanese white-collar employees[J]. Sleep, 2003, 26(4): 467-471.
[63]	Ayaki M, Shiba D, Negishi K, et al. Depressed visual field and mood are associated with sleep disorder in glaucoma patients[J]. Sci Rep, 2016, 6: 25699.
[64]	Rosenthal P, Borsook D. Ocular neuropathic pain[J]. Br J Ophthalmol, 2016, 100(1): 128-134.
[65]	Abad VC, Sarinas PS, Guilleminault C. Sleep and rheumatologic disorders[J]. Sleep Med Rev, 2008, 12(3): 211-228.
[66]	Sivertsen B, Lallukka T, Petrie KJ, et al. Sleep and pain sensitivity in adults[J]. Pain, 2015, 156(8): 1433-1439.
[67]	Wang Y, Lv H, Liu Y, et al. Characteristics of symptoms experienced by persons with dry eye disease while driving in China[J]. Eye (Lond), 2017, 31(11): 1550-1555.
[68]	Deschamps N, Ricaud X, Rabut G, et al. The impact of dry eye disease on visual performance while driving[J]. Am J Ophthalmol, 2013, 156(1): 184-189.
[69]	Tong L, Waduthantri S, Wong TY, et al. Impact of symptomatic dry eye on vision-related daily activities: the Singapore Malay Eye Study[J]. Eye (Lond), 2010, 24(9): 1486-1491.
[70]	van Tilborg MM, Murphy PJ, Evans KS. Impact of dry eye symptoms and daily activities in a modern office[J]. Optom Vis Sci, 2017, 94(6): 688-693.
[71]	Mathews PM, Ramulu PY, Swenor BS, et al. Functional impairment of reading in patients with dry eye[J]. Br J Ophthalmol, 2017, 101(4): 481-486.
[72]	van Landingham SW, West SK, Akpek EK, et al. Impact of dry eye on reading in a population-based sample of the elderly: the Salisbury Eye Evaluation[J]. Br J Ophthalmol, 2014, 98(5): 639-644.
[73]	Ridder WH, Zhang Y, Huang JF. Evaluation of reading speed and contrast sensitivity in dry eye disease[J]. Optom Vis Sci, 2013, 90(1): 37-44.
[74]	Karakus S, Mathews PM, Agrawal D, et al. Impact of dry eye on prolonged reading[J]. Optom Vis Sci, 2018, 95(12): 1105-1113.
[75]	Sun MJ, Rubin GS, Akpek EK, et al. Impact of glaucoma and dry eye on text-based searching[J]. Transl Vis Sci Technol, 2017, 6(3): 24.
[76]	Karakus S, Agrawal D, Hindman HB, et al. Effects of prolonged reading on dry eye[J]. Ophthalmology, 2018, 125(10): 1500-1505.
[77]	Yu J, Asche CV, Fairchild CJ. The economic burden of dry eye disease in the United States: a decision tree analysis[J]. Cornea, 2011, 30(4): 379-387.
[78]	Clegg JP, Guest JF, Lehman A, et al. The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists[J]. Ophthalmic Epidemiol, 2006, 13(4): 263-274.
[79]	Mizuno Y, Yamada M, Shigeyasu C. Annual direct cost of dry eye in Japan[J]. Clin Ophthalmol, 2012, 6: 755-760.
[80]	Lerner D, Amick BC, Lee JC, et al. Relationship of employee-reported work limitations to work productivity[J]. Med Care, 2003, 41(5): 649-659.
[81]	Patel VD, Watanabe JH, Strauss JA, et al. Work productivity loss in patients with dry eye disease: an online survey[J]. Curr Med Res Opin, 2011, 27(5): 1041-1048.
[82]	Craig JP, Tomlinson A. Importance of the lipid layer in human tear film stability and evaporation[J]. Optometry Vision Sci, 1997, 74(1): 8-13.
[83]	Tomlinson A, Doane MG, McFadyen A. Inputs and outputs of the lacrimal system: Review of production and evaporative loss[J]. Ocul Surf, 2009, 7(4): 186-198.
[84]	Koh S, Maeda N, Hori Y, et al. Effects of suppression of blinking on quality of vision in borderline cases of evaporative dry eye[J]. Cornea, 2008, 27(3): 275-278.
[85]	Begley CG, Himebaugh N, Renner D, et al. Tear breakup dynamics: A technique for quantifying tear film instability[J]. Optometry Vision Sci, 2006, 83(1): 15-21.
[86]	Miljanoviĉ B, Dana R, Sullivan DA, et al. Impact of dry eye syndrome on vision-related quality of life[J]. Am J Ophthalmol, 2007, 143(3): 409-415.
[87]	Choy EPY, Cho P, Benzie IFF, et al. Dry eye and blink rate simulation with a pig eye model[J]. Optometry Vision Sci, 2008, 85(2): 129-134.
[88]	Sheedy JE, Truong SD, Hayes JR. What are the visual benefits of eyelid squinting？[J]. Optometry Vision Sci, 2003, 80(11): 740-744.
[89]	Tsubota K. Tear dynamics and dry eye[J]. Prog Retin Eye Res, 1998, 17(4): 565-596.
[90]	Harrison WW, Begley CG, Liu H, et al. Menisci and fullness of the blink in dry eye[J]. Optometry Vision Sci, 2008, 85(8): 706-714.
[91]	Sun WS, Baker RS, Chuke JC, et al. Age-related changes in human blinks: Passive and active changes in eyelid kinematics[J]. Invest Ophthalmol Vis Sci, 1997, 38(1): 92-99.
[92]	Sheedy JE, Gowrisankaran S, Hayes JR. Blink rate decreases with eyelid squint[J]. Optometry Vision Sci, 2005, 82(10): 905-911.
[93]	Himebaugh NL, Begley CG, Bradley A, et al. Blinking and tear break-up during four visual tasks[J]. Optometry Vision Sci, 2009, 86(2): E106-E114.
[94]	Katayama I, Koyano T, Nishioka K. Prevalence of eyelid dermatitis in primary Sjogren′s syndrome[J]. Int J Dermatol, 1994, 33(6): 421-424.

[1]	陈翠萍, 李佩君, 杜景榕, 谢青梅, 许一宁, 卓姝妤, 李晓芳. 互联网联合上门护理在老年全髋关节置换术后的应用效果[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 676-681.
[2]	李萍, 陈慧, 庄君龙. 快速康复外科在机器人辅助腹腔镜膀胱切除回肠造口术中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(03): 249-253.
[3]	刘欣茹, 杜鹃, 代健健, 辛秀娟, 高梨梨. SBAR沟通模式在急诊腹股沟疝手术患者中的应用研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 451-455.
[4]	孙红燕, 李娟. 造口旁疝患者生活质量的影响因素分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 273-276.
[5]	张璇, 高杨, 房雅君, 姚艳玲. 保护性机械通气在肺癌胸腔镜肺段切除术中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 563-567.
[6]	马锦芳, 何正光, 郑劲平. 盐酸氨溴索雾化吸入治疗慢性阻塞性肺疾病黏痰症患者的疗效和安全性分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 568-574.
[7]	陶银花, 张红杰, 王亚岚, 陈莲, 张珺. 间歇式气压治疗预防肺癌化疗下肢深静脉血栓的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 605-608.
[8]	林建琴, 孔令敏, 陆银凤, 陈勇, 金凤, 叶磊, 陈方梅. PERMA模式对肺癌患者治疗获益感及生活质量的影响分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 634-638.
[9]	罗孝平, 封敏, 黄川, 唐茜, 蒋艳, 胡莉丽. 渐进式抗阻训练干预在非小细胞肺癌中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 472-474.
[10]	李临川, 李戊阳, 程玉刚, 朱健康, 张光永. 近端胃切除术后消化道重建方式的现状与展望[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(03): 135-140.
[11]	赵磊, 刘文志, 林峰, 于剑, 孙铭骏, 崔佑刚, 张旭, 衣宇鹏, 于宝胜, 冯宁. 深部热疗在改善结直肠癌术后辅助化疗副反应及生活质量中的作用研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 488-493.
[12]	汪毅仁, 江晓丹, 李佳曦, 赵天瑶, 李学民. 干眼的症状、体征与焦虑及抑郁相关性的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 212-216.
[13]	刘涵, 张蓝月, 沈强. 眼表重建技术的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 182-186.
[14]	高建平, 王辉, 王淑萍. 定期家庭随访对胸腔镜食管癌术后饮食恢复功能的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(02): 188-192.
[15]	周佳佳, 俞莹, 梁舒. 视频终端视相关性干眼症的机制研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 402-406.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Advances on the effects of dry eye disease on quality of life

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Advances on the effects of dry eye disease on quality of life