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中华眼科医学杂志(电子版) ›› 2018, Vol. 08 ›› Issue (02) : 92 -96. doi: 10.3877/cma.j.issn.2095-2007.2018.02.008

所属专题: 文献

综述

年龄相关性黄斑变性相关危险因素的研究进展
王皓1, 刘苏1,()   
  1. 1. 400010 重庆医科大学附属第二医院眼科
  • 收稿日期:2018-03-21 出版日期:2018-04-28
  • 通信作者: 刘苏
  • 基金资助:
    重庆市医学科技计划项目(201002146)

The new resarch progress of risk factors of agerelated macular degeneration

Hao Wang1, Su Liu1,()   

  1. 1. Departartment of Ophthalmology, Second Affiliated Hosipital of Chongqing Medical University, Chongqing 400010, China
  • Received:2018-03-21 Published:2018-04-28
  • Corresponding author: Su Liu
  • About author:
    Corresponding author: Liu Su, Email:
引用本文:

王皓, 刘苏. 年龄相关性黄斑变性相关危险因素的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2018, 08(02): 92-96.

Hao Wang, Su Liu. The new resarch progress of risk factors of agerelated macular degeneration[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2018, 08(02): 92-96.

年龄相关性黄斑变性(AMD)是全球主要的致盲性眼部疾病之一,但是其发病机制尚未完全明确。国内外研究学者普遍认为,个体因素、环境因素、全身因素及遗传因素为其主要的致病危险因素,如年龄、性别、种族、吸烟及全身相关疾病等。目前,全球对AMD流行病学相关危险因素的研究均有较大进展,故本文就AMD发病相关危险因素进行综述。

Age-related macular degeneration (AMD) is one of the major blinding eye diseases in the world, but its pathogenesis is not yet clear. It is generally believed that individual factors, environmental factors, systemic factors and genetic factors are the main risk factors for the disease, such as age, sex, race, smoking and general related diseases. At present, there are great progress in the research of AMD epidemiology related risk factors in the world. Therefore, this article reviews the related risk factors of AMD.

[1]
Prokofyeva E, Zrenner E. Epidemiology of Major Eye Diseases Leading to Blindness in Europe: A Literature Review[J]. Ophthalmic Research, 2011, 47(4):171-188.
[2]
Yang K, Liang YB, Gao LQ, et al. Prevalence of Age-Related Macular Degeneration in a Rural Chinese Population: The Handan Eye Study[J]. Ophthalmology, 2011, 118(7):1395-1401.
[3]
World Health Organization and Tufts University. School of Nutrition and Policy[C]. Geneva: Switzerland, 2002.
[4]
Pai MK. Comparative study of nutritional status of elderly population living in the home for aged vs those living in the community[J]. Biomedical Research, 2011, 22(1):120-126.
[5]
Chakravarthy U, Wong TY, Fletcher A, et al. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis[J]. BMC Ophthalmology, 2010, 10(1):31.
[6]
Fisher DE, Jonasson F, Eiriksdottir G, et al. Age-related macular degeneration and mortality in community-dwelling elders: the age, gene/environment susceptibility Reykjavik study[J]. Ophthalmology, 2015, 122(2):382-390.
[7]
葛坚. 眼科学[M]. 2版. 北京:人民卫生出版社,2013:314.
[8]
Cheung CM, Tai ES, Kawasaki R, et al. Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort[J]. Arch Ophthalmol, 2012, 130(4):480-486.
[9]
Klein R, Cruickshanks KJ, Nash SD, et al. The prevalence of age-related macular degeneration and associated risk factors[J]. Arch Ophthalmol, 2010, 128(6):750-758.
[10]
Foran S, Mitchell P, Wang JJ. Five-year change in visual acuity and incidence of visual impairment: the Blue Mountains Eye Study[J]. Ophthalmology, 2003, 110(1):41-50.
[11]
Yasuda M, Kiyohara Y, Hata Y, et al. Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population the Hisayama study.[J]. Ophthalmology, 2009, 116(11):2135-2140.
[12]
Mitchell P, Wang JJ, Foran S, et al. Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study[J]. Ophthalmology, 2002, 109(6):1092-1097.
[13]
Oshima Y, Ishibashi T, Murata T, et al. Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study[J]. Br J Ophthalmol, 2001, 85(10):1153-1157.
[14]
邹海东,张晳,许迅,等. 上海市静安区曹家渡街道年龄相关性黄斑变性的患病率调查[J]. 中华眼科杂志,2005,41(1):15-19.
[15]
田蔓男,张月梅,李丽,等. 老年性黄斑变性的流行病学调查[J]. 兰州大学学报(医学版),2005,31(2):70-71.
[16]
Clemons TE, Milton RC, Klein R, et al. Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19[J]. Ophthalmology, 2005, 112(4):533-539.
[17]
Jager RD, Mieler WF, Miller JW. Age-related macular degeneration[J]. N Engl J Med, 2008, 358(24):2606-2617.
[18]
Kawasaki R, Yasuda M, Song SJ, et al. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis[J]. Ophthalmology, 2010, 117(5):921-927.
[19]
Sang JP, Kwon KE, Choi NK, et al. Prevalence and Incidence of Exudative Age-Related Macular Degeneration in South Korea: A Nationwide Population-Based Study[J]. Ophthalmology, 2015, 122(10):2063-2070.
[20]
Fraserbell S, Wu J, Klein R, et al. Smoking, alcohol intake, estrogen use, and age-related macular degeneration in Latinos: the Los Angeles Latino Eye Study[J]. Am J Ophthalmol, 2006, 141(1):79-87.
[21]
Sang JP, Ju HL, Woo SJ, et al. Age-Related Macular Degeneration: Prevalence and Risk Factors from Korean National Health and Nutrition Examination Survey, 2008 through 2011[J]. Ophthalmology, 2014, 121(9):1756-1765.
[22]
侯慧媛,王雨生. 吸烟与年龄相关性黄斑变性[J]. 国际眼科纵览,2007, 31(5):330-333.
[23]
Seddon JM, George S, Rosner B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration[J]. Digest of the World Core Medical Journals, 2006, 124(7):995-1001.
[24]
Tan JS, Mitchell P, Smith W, et al. Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study[J]. Ophthalmology, 2007, 114(6):1143-1150.
[25]
Bhatiwada N, Sheshappa MB, Prabhu P, et al. Dietary and lifestyle risk factors associated with age-related macular degeneration: A hospital based study[J]. Indian Journal of Ophthalmology, 2013, 61(12):722-727.
[26]
Sui GY, Liu GC, Liu GY, et al. Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis[J]. Br J Ophthalmol, 2013, 97(4):389-394.
[27]
Youn HY, Mccanna DJ, Sivak JG, et al. In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells[J]. Molecular Vision, 2011, 17(28):237-246.
[28]
Sheng H, Lu Y, Fengling QL. Effects of Light Exposure and Use of Intraocular Lens on Retinal Pigment Epithelial Cells In Vitro[J]. Photochemistry & Photobiology, 2009, 85(4):966-969.
[29]
Lim LS, Mitchell P, Seddon JM, et al. Age-related macular degeneration[J]. Lancet, 2012, 379(9827):1728-1738.
[30]
Kolár P. Epidemiology of the age-related macular degeneration[J]. Ceská A Slovenská Oftalmologie, 2010, 66(3):127-130.
[31]
Tomany SC, Cruickshanks KJ, Klein R, et al. Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study.[J]. Archives of Ophthalmology, 2004, 122(5):750-757.
[32]
范瑞,潘星月,杨红梅,等. 老年黄斑变性患者影响因素对照调查分析[J]. 中国实用眼科杂志,2009, 27(9):1048-1050.
[33]
Mares JA, Moeller SM. Diet and age-related macular degeneration: expanding our view[J]. American Journal of Clinical Nutrition, 2006, 83(4):733-734.
[34]
Sangiovanni JP, Chew EY, Agrón E, et al. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23[J]. Arch Ophthalmol, 2008, 126(9):1274-1279.
[35]
BialekSzymańska A, MisiukHojo M, Witkowska K. Risk factors evaluation in age-related macular degeneration[J]. Klinika Oczna, 2007, 109(4):127-130.
[36]
Seddon JM, Cote J, Rosner B. Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake[J]. Arch Ophthalmol, 2003, 121(12):1728-1737.
[37]
Tomany SC, Klein R, Klein BE. The relationship between iris color, hair color, and skin sun sensitivity and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study[J]. Ophthalmology, 2003, 110(8):1526-1533.
[38]
Rosen ES. Age-related macular degeneration and cataract surgery[J]. J Cataract Refract Surg, 2014, 40(2):173-174.
[39]
Ula F, Balbaba M, Özmen S, et al. Association of dehydroepiandrosterone sulfate, serum lipids, C-reactive protein and body mass index with age-related macular degeneration[J]. International Ophthalmology, 2013, 33(5):485-491.
[40]
Ikram MK, Van LR, Vingerling JR, et al. Relationship between refraction and prevalent as well as incident age-related maculopathy: the Rotterdam Study[J]. Invest Ophthalmol Vis Sci, 2003, 44(9):3778-3782.
[41]
Choi JK, Lym YL, Moon JW, et al. Diabetes Mellitus and Early Age-related Macular Degeneration[J]. Arch Ophthalmol, 2011, 129(2):196-199.
[42]
Chen X, Rong SS, Xu Q, et al. Diabetes mellitus and risk of age-related macular degeneration: a systematic review and meta-analysis[J]. PloS One, 2014, 9(9):e108196.
[43]
Woo SJ, Ahn J, Morrison MA, et al. Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration[J]. PloS One, 2015, 10(7):e0132771.
[44]
Erke MG, Bertelsen G, Peto T, et al. Prevalence of age-related macular degeneration in elderly Caucasians: the Tromsø Eye Study[J]. Ophthalmology, 2012, 119(9):1737-1743.
[45]
Seddon JM, Cote J, Davis N, et al. Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio[J]. Arch Ophthalmol, 2003, 121(6):785-792.
[46]
Sun Y, Yu W, Huang L, et al. Is asthma related to choroidal neovascularization?[J]. PloS One, 2012, 7(5):e35415.
[47]
Kahawita SK, Casson RJ. Aspirin use and early age-related macular degeneration: a meta-analysis[J]. Canadian Journal of Ophthalmology Journal Canadien Dophtalmologie, 2014, 49(1):35-39.
[48]
Meyers SM. A twin study on age-related macular degeneration[J]. Transactions of the American Ophthalmological Society, 1994, 92(2):775-843.
[49]
Seddon JM, Gensler G, Milton RC, et al. Association between C-reactive protein and age-related macular degeneration[J]. Jama, 2004, 137(5):704-710.
[50]
Klaver CC, Kliffen M, van Duijn CM, et al. Genetic association of apolipoprotein E with age-related macular degeneration[J]. American Journal of Human Genetics, 1998, 63(1):200-206.
[51]
Vingerling JR, Dielemans I, Bots ML, et al. Age-related Macular Degeneration Is Associated with Atherosclerosis: The Rotterdam Study[J]. American Journal of Epidemiology, 1995, 142(4):404-409.
[52]
Boekhoorn SS, Isaacs A, Uitterlinden AG, et al. Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study[J]. Ophthalmology, 2008, 115(11):1899-1903.
[53]
Katta S, Kaur I, Chakrabarti S. The molecular genetic basis of age-related macular degeneration: an overview[J]. Journal of Genetics, 2010, 88(4):425-449.
[54]
Chen Y, Zeng J, Zhao C, et al. Assessing Susceptibility to Age-Related Macular Degeneration With Genetic Markers and Environmental Factors[J]. Arch Ophthalmol, 2011, 129(3):344-351.
[55]
Havvas I, Marioli DI, Deli A, et al. Complement C3, C2, and factor B gene polymorphisms and age-related macular degeneration in a Greek cohort study[J]. European Journal of Ophthalmology, 2014, 24(5):751-760.
[56]
Contreras AV, Zenteno JC, Rodríguezcorona U, et al. CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans[J]. Molecular Vision, 2014, 20(1):105-116.
[57]
Restrepo NA, Spencer KL, Goodloe R, et al. Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study[J]. Invest Ophthalmol Vis Sci, 2014, 55(10):6839-6850.
[58]
Yu Y, Bhangale TR, Fagerness J, et al. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration[J]. Human Molecular Genetics, 2011, 20(18):3699-3709.
[59]
Murad N, Kokkinaki M, Gunawardena N, et al. miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration[J]. Febs Journal, 2015, 281(23):5251-5264.
[60]
Klein R, Klein BEK, Tomany SC, et al. Ten-Year Incidence of Age-related Maculopathy and Smoking and Drinking: The Beaver Dam Eye Study[J]. Am J Epidemiol, 2002, 156(7):589-598.
[61]
Algvere PV, Seregard S. Drusen maculopathy: a risk factor for AMD. Can we prevent visual loss?[J]. Acta Ophthalmologica Scandinavica, 2003, 81(5):427-429.
[62]
Wu KH, Madigan MCBillson FA, Penfold PL. Differential expression of GFAP in early v late AMD: a quantitative analysis[J]. Br J Ophthalmol, 2003, 87(9):1159-1166.
[63]
Nilsson UL, Frennesson CNilsson SE. Patients with AMD and a large absolute central scotoma can be trained successfully to use eccentric viewing, as demonstrated in a scanning laser ophthalmoscope[J]. Vision Research, 2003, 43(16):1777-1787.
[64]
Miller DW, Joussen AM, Holz FG. Die molekularen Mechanismender neovaskularen AMD[J]. Der Ophthalmologe, 2003, 100(2):92-96.
[65]
Eter N, Vogel A, Inhetvin-Hutter C, et al. Interval reduction of photodynamic therapy (PDT) in age-related macular degeneration (AMD) is not advantageous. A pilot project[J]. Der Ophthalmologe, 2003, 100(4):314-317.
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