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中华眼科医学杂志(电子版) ›› 2017, Vol. 07 ›› Issue (01) : 1 -5. doi: 10.3877/cma.j.issn.2095-2007.2017.01.001

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重视飞秒激光角膜屈光术前Avellino角膜营养不良的临床检查和基因筛查
李玉1, 张丰菊1,†()   
  1. 1. 100730　首都医科大学附属北京同仁医院北京同仁眼科中心　北京市眼科学与视觉科学重点实验室
  • 收稿日期:2017-01-12 出版日期:2017-02-28
  • 通信作者: 张丰菊
  • 基金资助:
    北京市卫生系统高层次卫生技术人才培养计划(2013－2－023)

Pay attention to clinical examination and genetic screening of Avellino corneal dystrophy before femtosecond laser corneal refractive surgery

Yu Li1, Fengju Zhang1,†()   

  1. 1. Beijing Tongren Hospital of Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China
  • Received:2017-01-12 Published:2017-02-28
  • Corresponding author: Fengju Zhang
  • About author:
    Corresponding author: Zhang Fengju, Email:
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李玉, 张丰菊. 重视飞秒激光角膜屈光术前Avellino角膜营养不良的临床检查和基因筛查[J]. 中华眼科医学杂志(电子版), 2017, 07(01): 1-5.

Yu Li, Fengju Zhang. Pay attention to clinical examination and genetic screening of Avellino corneal dystrophy before femtosecond laser corneal refractive surgery[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2017, 07(01): 1-5.

随着飞秒激光技术的快速发展，多元化的角膜屈光手术给屈光不正患者带来了满意的临床效果。同时，飞秒激光角膜屈光术的安全性、有效性、稳定性及可预测性均得到了进一步的提高。然而，伴有角膜营养不良的屈光不正患者，尤其是Avellino角膜营养不良的年轻患者，在行飞秒激光角膜屈光术后，其病情将进一步加重，从而对视功能造成影响。本文中笔者对国内外报道的伴有Avellino角膜营养不良的屈光不正患者在行角膜屈光手术后，出现的角膜混浊程度加重、视力下降等情况进行分析，归纳已经报道的Avellino角膜营养不良的临床表现和基因筛查位点。研究结果表明，Avellino角膜营养不良应列为飞秒激光角膜屈光术的绝对禁忌证，故建议临床医师应在行飞秒激光角膜屈光术前加强对Avellino角膜营养不良的临床检查和基因筛查。

关键词: 角膜屈光手术, 飞秒激光, Avellino角膜营养不良, 临床检查, 基因筛查, 禁忌证

With the rapid development of femtosecond laser technology, diversified corneal refractive surgeries bring satisfactory clinical effect for patients with ametropia. At the same time, the safety, effectiveness, stability and predictability of femtosecond laser corneal refractive surgery have been further improved. However, for ametropia patients with corneal dystrophy, especially for those young patients with Avellino corneal dystrophy, who have accepted femtosecond laser refractive surgery, their conditions will be further aggravated, thus affecting the visual function of them. In this paper, aggravation of maculae corneae and decreased vision of ametropia patients with Avellino corneal dystrophy after femtosecond laser refractive surgery were covered, as well as the clinical manifestations and gene screening sites of Avellino corneal dystrophy. Avellino corneal dystrophy is an absolute contraindication of femtosecond laser corneal refractive surgery. Therefore, Clinicians should strengthen the clinical examination and gene screening of Avellino corneal dystrophy before femtosecond laser corneal refractive surgery.

Key words: Cornea refractive surgery, Femtosecond laser, Avellino corneal dystrophy, Clinical examination, Genetic screening, Contraindication
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