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中华眼科医学杂志(电子版) ›› 2026, Vol. 16 ›› Issue (02) : 116 -121. doi: 10.3877/cma.j.issn.2095-2007.2026.02.010

综述

青光眼与焦虑或抑郁双向相关性的研究进展
徐涛1, 刘含若2,()   
  1. 1100730 首都医科大学附属北京同仁医院2025级硕士研究生
    2100730 首都医科大学附属北京同仁医院 北京市眼科研究所
  • 收稿日期:2025-10-27 出版日期:2026-04-28
  • 通信作者: 刘含若
  • 基金资助:
    国家自然科学基金面上项目(82171051); 国家自然科学基金面上项目(82371053); 国家自然科学基金优秀青年科学基金项目(82422018)

Research progress on the bidirectional correlation between glaucoma and anxiety or depression

Tao Xu1, Hanruo Liu2,()   

  1. 1Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    2Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing 100730, China
  • Received:2025-10-27 Published:2026-04-28
  • Corresponding author: Hanruo Liu
引用本文:

徐涛, 刘含若. 青光眼与焦虑或抑郁双向相关性的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2026, 16(02): 116-121.

Tao Xu, Hanruo Liu. Research progress on the bidirectional correlation between glaucoma and anxiety or depression[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2026, 16(02): 116-121.

既往观点认为,青光眼为单纯的视觉通道疾病,对患者的心理社会关注较少。众多流行病学证据表明,焦虑或抑郁在青光眼患者中的患病率远远高于一般人群,焦虑或抑郁是青光眼患病和发展的危险因素,两者相互影响,甚至形成恶性循环,两者相互促进的机制包括神经内分泌因素、自主神经因素及心理社会因素等。同时,青光眼与焦虑或抑郁的关联受人口学因素、体质因素及脑来源神经生长因子(BDNF)的影响,目前的研究结果已经证实青光眼与焦虑或抑郁存在双向关联性。这强调了在青光眼临床管理中将心理健康评估纳入常规诊疗体系的必要性。

The previous view was that glaucoma is a simple visual channel disease that requires less attention to the psychological and social well-being of patients. Numerous epidemiological evidences indicate that the prevalence of anxiety or depression in glaucoma patients is much higher than that in the general population. Anxiety or depression is a risk factor for the onset and development of glaucoma, and the two interact with each other, even forming a vicious cycle. The mechanism of mutual promotion between the two includes neuroendocrine factors, autonomic factors, and psychosocial factors. Meanwhile, the association between glaucoma and anxiety or depression is influenced by demographic factors, physical factors, and brain-derived neurotrophic factor (BDNF). Current research has confirmed a bidirectional association between glaucoma and anxiety or depression. This emphasizes the necessity of incorporating mental health assessment into the routine diagnosis and treatment system in the clinical management of glaucoma.

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