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中华眼科医学杂志(电子版) ›› 2026, Vol. 16 ›› Issue (02) : 65 -69. doi: 10.3877/cma.j.issn.2095-2007.2026.02.001

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重视翼状胬肉手术时机、术式及术后并发症处理方式的选择
张鹏1, 杨极1, 刘海1,(), 刘涛2   
  1. 1650000 云南省昆明,云南大学附属医院(云南省第二人民医院、云南省眼科医院)云南省眼部疾病临床医学研究中心 云南省眼病临床医学中心
    2650000 云南省昆明,云南大学校医院
  • 收稿日期:2026-01-03 出版日期:2026-04-28
  • 通信作者: 刘海
  • 基金资助:
    国家自然科学基金项目(82460201); 云南大学医学科研基金项目(YDYXJJ2024-0003)

Emphasize the selection of surgical timing, surgical methods, and postoperative complication management for pterygium

Peng Zhang1, Ji Yang1, Hai Liu1,(), Tao Liu2   

  1. 1Yunnan University Affiliated Hospital (Yunnan Second People′s Hospital, Yunnan Eye Hospital) Yunnan Eye Disease Clinical Medical Research Center Yunnan Eye Disease Clinical Medical Center, Kunming 650000, China
    2Yunnan University Hospital, Kunming 650000, China
  • Received:2026-01-03 Published:2026-04-28
  • Corresponding author: Hai Liu
引用本文:

张鹏, 杨极, 刘海, 刘涛. 重视翼状胬肉手术时机、术式及术后并发症处理方式的选择[J/OL]. 中华眼科医学杂志(电子版), 2026, 16(02): 65-69.

Peng Zhang, Ji Yang, Hai Liu, Tao Liu. Emphasize the selection of surgical timing, surgical methods, and postoperative complication management for pterygium[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2026, 16(02): 65-69.

翼状胬肉作为一种全球性的常见眼表疾病,影响患者视力与外观,严重者可致盲。目前,常见的手术方式包括单纯胬肉切除术、胬肉转位术、角膜缘干细胞联合自体结膜移植术及羊膜移植术等。其手术疗法虽历经演变,但术后复发及并发症的发生仍是困扰患者与临床医师的核心挑战。对其手术时机、术式及术后并发症处理方式的选择关系到患者术后眼表稳态及复发率,须遵从循证医学证据,综合考量胬肉的进展性及其对患者视觉功能和生活质量的影响。以角膜缘干细胞联合结膜移植为代表的重建性术式能有效降低术后复发率,是目前胬肉手术疗法的基石,而对术后复发及手术相关干眼等并发症管理是保障远期疗效的关键。未来,结合新型生物疗法和组织工程学成果的个性化疗法,将是翼状胬肉精准、微创治疗的发展方向。

Pterygium, as a common global ocular surface disease, affects patients′ vision and appearance, and can lead to blindness in severe cases. The common surgical methods currently include simple pterygium excision, pterygium transposition, corneal limbal stem cell combined with autologous conjunctival transplantation, and amniotic membrane transplantation. Although its surgical therapy has undergone evolution, postoperative recurrence and complications remain the core challenges that plague patients and clinical physicians. The choice of surgical timing, procedure, and postoperative complication management is related to the patient's postoperative ocular surface stability and recurrence rate. Evidence based medicine should be followed to comprehensively consider the progression of pterygium and its impact on the patient's visual function and quality of life. The reconstructive surgical technique represented by corneal limbal stem cell combined with conjunctival transplantation can effectively reduce the postoperative recurrence rate and is the cornerstone of current pterygium surgical therapy. The management of postoperative recurrence and surgical related complications such as dry eye is the key to ensuring long-term efficacy. In the future, personalized therapies combining new biological therapies and tissue engineering achievements will be the development direction for precise and minimally invasive treatment of pterygium.

[1]
Nemesure B, Wu SY, Hennis A, et al. Nine-Year Incidence and Risk Factors for Pterygium in the Barbados Eye Studies[J]. Ophthalmology, 2008, 115(12): 2153-2158.
[2]
Cajucom H, Tong L, Wong TY, et al. The prevalence of and risk factors for pterygium in an urban Malay population: The Singapore Malay Eye Study (SiMES)[J]. British Journal of Ophthalmology, 2010, 94(8): 977-981.
[3]
Fernandes AG, Salomão SR, Ferraz NN, et al. Pterygium in adults from the Brazilian Amazon Region[J]. British Journal of Ophthalmology, 2020, 104(6): 757-763.
[4]
Ma K, Xu L, Jie Y, et al. Prevalence of and Factors Associated With Pterygium in Adult Chinese: The Beijing Eye Study[J]. Cornea, 2007, 26(10): 1184-1186.
[5]
柯红琴,张文佳,刘海,等. 云南省文山州40岁及以上壮族和苗族人群翼状胬肉患病率及其影响因素[J]. 国际眼科杂志202222(2):347-351.
[6]
柯红琴,董宇婕,刘海,等. 云南省6个地区农村人群翼状胬肉患病率及其影响因素的研究[J]. 中华眼科杂志202258(10):769-777.
[7]
吕伟,梁远波,孙兰萍,等. 翼状胬肉的患病率及危险因素[J]. 国际眼科纵览200933(3):170-173.
[8]
李训,钟华,袁援生. 翼状胬肉的流行病学[J]. 国际眼科纵览201135(2):106-110.
[9]
Safi H, Kheirkhah A, Mahbod M, et al. Correlations Between Histopathologic Changes and Clinical Features in Pterygia[J]. Journal of Ophthalmic & Vision Research, 2016, 11(2): 153-158.
[10]
Koc M, Uzel MM, Aydemir E, et al. Pterygium size and effect on intraocular lens power calculation[J]. Journal of Cataract and Refractive Surgery, 2016, 42(11): 1620-1625.
[11]
吕慧验,张守英,张秀传. 翼状胬肉的手术时机探讨[J]. 青岛大学医学院学报201753(4):470-471.
[12]
孟宪虎,尹万昕,王淑晶,等. 原发性翼状胬肉手术时机临床观察[J]. 中华眼外伤职业眼病杂志201133(2):133-135.
[13]
钟新娜,吴元奇,曹岐新,等. 翼状胬肉手术时机的临床研究[J]. 浙江中医药大学学报200731(1):74-75.
[14]
Chu WK, Choi HL, Bhat AK, et al. Pterygium: new insights[J]. Eye, 2020, 34(6): 1047-1050.
[15]
刘爽. 暴露巩膜法翼状胬肉切除术与改良手术效果的对比观察[J]. 中国冶金工业医学杂志200421(6):2-4.
[16]
Kenyon KR, Wagoner MD, Hettinger ME. Conjunctival Autograft Transplantation for Advanced and Recurrent Pterygium[J]. Ophthalmology, 1985, 92(11): 1461-1470.
[17]
Schermer A, Galvin S, Sun TT. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.[J]. The Journal of cell biology, 1986, 103(1): 49-62.
[18]
宋伟涛,夏晓波,邝国平,等. 自体角膜缘干细胞移植与结膜瓣转位治疗翼状胬肉的对比研究[J]. 眼科新进展200929(5):376-378.
[19]
夏红和,严宗辉. 翼状胬肉切除联合自体角膜缘干细胞移植治疗原发性翼状胬肉的Meta分析[J]. 眼科新进展201030(4):361-366.
[20]
王乐滢,梁庆丰. 角膜缘干细胞移植术的研究进展[J]. 中华眼科杂志202056(12):956-960.
[21]
Shimazaki J, Yang HY, Tsubota K. Amniotic Membrane Transplantation for Ocular Surface Reconstruction in Patients with Chemical and Thermal Burns[J]. Ophthalmology, 1997, 104(12): 2068-2076.
[22]
Clearfield E, Muthappan V, Wang X, et al. Conjunctival autograft for pterygium[J]. Cochrane Database of Systematic Reviews, 2016, 2(2): CD011349.
[23]
Luanratanakorn P, Ratanapakorn T, Suwan-apichon O, et al. Randomised controlled study of conjunctival autograft versus amniotic membrane graft in pterygium excision[J]. British Journal of Ophthalmology, 2006, 90(12): 1476-1480.
[24]
吴婷婷,晏艳霜,方琦琦. 翼状胬肉切除联合干性与湿性羊膜移植治疗原发性翼状胬肉的疗效比较[J]. 国际眼科杂志202222(11):1908-1912.
[25]
于静,冯珺,接英,等. 改良的翼状胬肉切除联合自体结膜和羊膜移植术及干扰素滴眼液治疗原发性翼状胬肉的初步疗效观察[J]. 中华眼科杂志202056(10):768-773.
[26]
肖燕,王骞,朱俊英. 翼状胬肉切除术联合不同移植术的临床效果比较[J]. 中华眼外伤职业眼病杂志202547(7):542-548.
[27]
文小凤,柯敏. 不同术式治疗复发性翼状胬肉疗效的系统评价[J]. 中国循证医学杂志201212(11):1379-1384.
[28]
张琦,项振扬. 角膜缘干细胞移植术和羊膜移植术治疗复发性翼状胬肉的比较[J]. 中国实用眼科杂志200624(5):505-507.
[29]
李勇,岳章显,刘钊臣,等. 翼状胬肉术后应用环孢素A和MMC的临床对比研究[J]. 国际眼科杂志201313(1):179-180.
[30]
尹明阳,潘志强. 药物预防翼状胬肉的复发[J]. 国际眼科纵览201842(2):129-133.
[31]
Matsuda S, Koyasu S. Mechanisms of action of cyclosporine[J]. Immunopharmacology, 2000, 47(2-3): 119-125.
[32]
钟益科,袁建树. 翼状胬肉术后应用环孢素和氟尿嘧啶的临床对比观察[J]. 中国药房201425(8):725-726.
[33]
Martins T GDS, Costa ALF de A, Alves MR, et al. Mitomycin C in pterygium treatment[J]. International Journal of Ophthalmology, 2016, 9(3): 465-468.
[34]
Raiskup F. Mitomycin C for pterygium: long term evaluation[J]. British Journal of Ophthalmology, 2004, 88(11): 1425-1428.
[35]
潘建兵,冯一帆. 环孢素A在防止翼状胬肉术后复发中作用的meta分析[J]. 中华实验眼科杂志201332(11):1069-1073.
[36]
Chui J, Girolamo ND, Wakefield D, et al. The Pathogenesis of Pterygium[J]. The Ocular Surface, 2008, 6(1): 24-43.
[37]
Zeng W, Liu Z, Dai H, et al. Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision[J]. BMC Ophthalmology, 2017, 17(1): 211.
[38]
Paul F, Pellegrini S, Uzé G. IFNA2: The prototypic human alpha interferon[J]. Gene, 2015, 567(2): 132-137.
[39]
Kikuchi I, Kase S, Ishijima K, et al. Long-term follow-up of conjunctival melanoma treated with topical interferon alpha-2b eye drops as adjunctive therapy following surgical resection[J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 2017, 255(11): 2271-2276.
[40]
Alvarado-Castillo B, Santa Cruz-Pavlovich FJ, Gonzalez-Castillo C, et al. Safety and efficacy of topical interferon alpha 2B and mitomycin C for localized conjunctival intraepithelial neoplasia: long-term report of their pharmacological safety and efficacy[J]. BMC Ophthalmology, 2023, 23(1): 335.
[41]
Yin M, Li H, Zhang Y, et al. Interferon Alpha-2b Eye Drops Prevent Recurrence of Pterygium After the Bare Sclera Technique[J]. Cornea, 2019, 38(10): 1239-1244.
[42]
于静,冯珺,接英,等. 羊膜移植联合干扰素滴眼液治疗原发性翼状胬肉效果评估[J]. 中华实验眼科杂志202038(8):686-691.
[43]
Noguera SI, Nicanor KSA, Ang RET, et al. Clinical outcomes of pterygium surgery over a ten-year period[J]. BMC Ophthalmology, 2025, 25(1): 380.
[44]
张军军,刘谊. 曲安奈德玻璃体腔内注射疗法的研究现状[J]. 中华眼底病杂志200521(4):203-204.
[45]
孟希,张美莎,刘和忠. 翼状胬肉切除联合角膜缘干细胞移植术后使用糖皮质激素的疗效观察[J]. 心理医生201723(34):92-94.
[46]
田若男,彭振宇. 翼状胬肉手术治疗及围术期处理研究进展[J]. 吉首大学学报(自然科学版)202546(1):85-89.
[47]
Koranyi G. Cut and paste: a no suture, small incision approach to pterygium surgery[J]. British Journal of Ophthalmology, 2004, 88(7): 911-914.
[48]
Panda A, Kumar S, Kumar A, et al. Fibrin glue in ophthalmology[J]. Indian Journal of Ophthalmology, 2009, 57(5): 371.
[49]
姜秦祥. 人纤维蛋白胶对翼状胬肉眼病患者术后结膜瓣植片变化的影响[J]. 抗感染药学201512(2):256-259.
[50]
Ozdamar Y, Mutevelli S, Han U, et al. A Comparative Study of Tissue Glue and Vicryl Suture for Closing Limbal-Conjunctival Autografts and Histologic Evaluation After Pterygium Excision[J]. Cornea, 2008, 27(5): 552-558.
[51]
Kodavoor SK, VP, Dandapani R. Profile of complications in pterygium surgery-A retrospective analysis[J]. Indian Journal of Ophthalmology, 2021, 69(7): 1697-1701.
[52]
魏勇,陈连萍,张戈非,等. 翼状胬肉自体结膜移植术后干眼症的原因[J]. 中国实用眼科杂志200220(6):456-457.
[53]
张功永,许振国. 丝裂霉素C溶液滴眼致巩膜坏死的救治[J]. 中国实用眼科杂志200523(6):641.
[54]
高华,孙秀丽,贾艳妮,等. 联合或不联合板层角膜移植的结膜瓣移植治疗巩膜坏死[J]. 中华眼视光学与视觉科学杂志201214(8):467-470.
[55]
任红燕,李霞,蔡岩. 翼状胬肉个体化临床治疗现状及展望[J]. 眼科学报202035(4):255-261.
[56]
陈俊杰,蓝育青,吴共发,等. VEGF诱导对翼状胬肉成纤维细胞血管生成拟态影响的研究[J]. 中华眼科医学杂志(电子版)20177(1):12-17.
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