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中华眼科医学杂志(电子版)

中华眼科医学杂志(电子版) ›› 2026, Vol. 16 ›› Issue (01) : 38 -42. doi: 10.3877/cma.j.issn.2095-2007.2026.01.007

综述

基于广域拼图技术对角膜上皮基底神经丛观察的研究进展
苏蕊1, 冯熠2, 渠敏2, 于花3, 赵炬伟4, 高妍2,†()   
  1. 1030001　太原，山西医科大学临床学科建设中心
    2030002　太原，山西省眼科医院准分子激光科室
    3030002　太原，山西省眼科医院角膜病科
    4030002　太原，山西省眼科医院综合检查科
  • 收稿日期:2026-01-15 出版日期:2026-02-28
  • 通信作者: 高妍
  • 基金资助:
    山西省人社厅择优资助项目(20210032); 山西省回国留学人员科技资助项目(2022-208)

Clinical application advances in observing the corneal sub-basal nerve plexus using wide-area pachymetry technology

Rui Su1, Yi Feng2, Min Qu2, Hua Yu3, Juwei Zhao4, Yan Gao2,†()   

  1. 1Clinical Discipline Construction Center of Shanxi Medical University, Taiyuan 030001, China
    2Department of Excimer Laser, Shanxi Eye Hospital, Taiyuan 030002, China
    3Department of Corneal Disease, Shanxi Eye Hospital, Taiyuan 030002, China
    4Department of Comprehensive Examination, Shanxi Eye Hospital, Taiyuan 030002, China
  • Received:2026-01-15 Published:2026-02-28
  • Corresponding author: Yan Gao
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苏蕊, 冯熠, 渠敏, 于花, 赵炬伟, 高妍. 基于广域拼图技术对角膜上皮基底神经丛观察的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2026, 16(01): 38-42.

Rui Su, Yi Feng, Min Qu, Hua Yu, Juwei Zhao, Yan Gao. Clinical application advances in observing the corneal sub-basal nerve plexus using wide-area pachymetry technology[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2026, 16(01): 38-42.

广域拼图技术结合深度学习算法极大地拓展了活体共聚焦显微镜(IVCM)的视野范围，使得宏观观察角膜上皮基底神经丛(SNP)成为可能。近年来，基于广域拼图技术对角膜SNP的观察应用广泛展开，获得了大量临床实践经验。本文中笔者就广域拼图技术在干眼、屈光术后、角膜胶原交联术后、糖尿病性神经病变以及帕金森病等疾病诊断、病情评估及治疗效果监测中的应用价值进行综述并对当前研究的不足和未来展望进行评述，期望为角膜神经改变的临床诊治和基础研究提供新视角与新思路。

关键词: 角膜上皮基底神经丛, 广域拼图, 活体共聚焦显微镜

Wide-field panoramic imaging combined with deep learning algorithms has significantly expanded the field of view of invasive in vivo confocal microscopy (IVCM), enabling macroscopic observation of the sub-basal nerve plexus of the cornea (SNP). The clinical applications and observation of wide-field panoramic imaging for studying corneal SNP in recent years has been perfomed, and extensive clinical practical experience has been gained. The value of this technology in the diagnosis, assessment and monitoring of treatment for diseases such as dry eye, post-refractive surgery, post-corneal cross-linking, diabetic neuropathy, and Parkinson′s disease were reviewed. Existing research limitations were listed and future prospects were outlined, proposing new approaches and perspectives for clinical diagnosis and treatment of corneal nerve alterations, as well as for basic research.

Key words: Corneal sub-basal nerve plexus, Wide-field stitching, In vivo confocal microscopy
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