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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (06) : 362 -366. doi: 10.3877/cma.j.issn.2095-2007.2022.06.008

综述

Dickkopf相关蛋白-1在眼部纤维化疾病中的研究进展
宋宇1, 包秀丽2,()   
  1. 1. 010050 呼和浩特,内蒙古医科大学第一临床医学院2020级硕士研究生
    2. 010050 呼和浩特,内蒙古医科大学附属医院眼科
  • 收稿日期:2022-04-05 出版日期:2022-12-28
  • 通信作者: 包秀丽
  • 基金资助:
    内蒙古自治区自然科学基金项目(2019MS08116)

Research progress of Dickkopf-1 in ocular fibrosis

Yu Song1, Xiuli Bao2,()   

  1. 1. Master′s degree 2020, First Clinical Medical College of Inner Mongolia Medical University, Hohhot 010050, China
    2. Department of Ophthalmology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
  • Received:2022-04-05 Published:2022-12-28
  • Corresponding author: Xiuli Bao
引用本文:

宋宇, 包秀丽. Dickkopf相关蛋白-1在眼部纤维化疾病中的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2022, 12(06): 362-366.

Yu Song, Xiuli Bao. Research progress of Dickkopf-1 in ocular fibrosis[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(06): 362-366.

纤维化是组织损伤修复的重要过程,而过度的纤维化常致使器官的结构破坏和功能丧失。无翅信号通路(WNT)通过调控机体内细胞增殖、更新及凋亡维持器官组织内稳态,若过度激活则导致机体发生纤维化疾病。Dickkopf相关蛋白(DKK)是WNT信号通路的内源性调节蛋白,Dickkopf相关蛋白-1(DKK1)通过竞争性结合WNT受体可抑制多种眼部纤维化疾病的发展。本文中笔者就国内外对DKK1在角膜纤维愈合、后发性白内障发病、眼底纤维化疾病进展及病理性近视眼中作用的研究进行综述。

Fibrosis is an important process of tissue damage and repair, while excessive fibrosis often leads to structural destruction and functional loss of organs. Wnt signal pathway (WNT) maintains homeostasis in organs and tissues by regulating cell proliferation, renewal and apoptosis in the body, while its over-activation leads to fibrosis in the body. Dickkopf-associated protein (DKK) is an endogenous regulatory protein of WNT. Dickkopf-associated protein 1 (DKK1) inhibits the development of various ocular fibrosis diseases by competing with WNT receptors. The role of DKK1 in the healing of corneal fibers, the occurrence of post-cataract, the progress of fundus fibrosis and pathological myopia were reviewed in this paper.

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