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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (04) : 232 -236. doi: 10.3877/cma.j.issn.2095-2007.2022.04.008

综述

M2型巨噬细胞极化在胸腺基质淋巴细胞生成素及其下游分子诱导过敏性结膜炎发病机制中作用的研究进展
高欢1, 郑晓汾2,()   
  1. 1. 030001 太原,山西医科大学第一临床医学院2019级硕士研究生
    2. 030002 太原,山西省眼科医院角膜病科
  • 收稿日期:2021-08-06 出版日期:2022-08-28
  • 通信作者: 郑晓汾
  • 基金资助:
    山西省重点研发计划项目(201803D31183)

The role of M2 macrophage polarization in the pathogenesis of allergic conjunctivitis involving TSLP and its downstream molecules

Huan Gao1, Xiaofen Zheng2,()   

  1. 1. Master′s degree 2019, the First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China
    2. Department of Keratology, Shanxi Eye Hospital, Taiyuan 030002, China
  • Received:2021-08-06 Published:2022-08-28
  • Corresponding author: Xiaofen Zheng
引用本文:

高欢, 郑晓汾. M2型巨噬细胞极化在胸腺基质淋巴细胞生成素及其下游分子诱导过敏性结膜炎发病机制中作用的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2022, 12(04): 232-236.

Huan Gao, Xiaofen Zheng. The role of M2 macrophage polarization in the pathogenesis of allergic conjunctivitis involving TSLP and its downstream molecules[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(04): 232-236.

过敏性结膜炎(AC)是人类眼表一种常见的过敏性疾病,发病原因复杂,主要是由免疫球蛋白E或T淋巴细胞介导的一种免疫反应。目前,过敏效应阶段细胞因子之间相互作用的分子机制已明确,但对过敏上游因子的了解却知之甚少。有研究结果表明,作为过敏上游因子的胸腺基质淋巴细胞生成素(TSLP)等具有启动和促过敏作用;此外,在短豚草花粉诱导实验性AC小鼠模型中已证实M2型巨噬细胞极化在辅助性T淋巴细胞2(Th2)显性过敏性炎症中有重要作用。目前,TSLP和M2型巨噬细胞在AC发病过程中的作用机制尚未完全阐明。因此,本文中笔者就M2型巨噬细胞极化在TSLP及其下游分子诱导AC发病机制中的作用进行综述。

Allergic conjunctivitis is a common allergic disease of human ocular surface. The causes of this disease are very complicated, mainly an immune response mediated by IgE or T lymphocytes. At present, the molecular mechanism of the interaction between cytokines in anaphylactic effect stage has been clearly demonstrated, but the understanding of the upstream factors of allergy is relatively poor. It has been demonstrated that thymic stromal lymphopoietin (TSLP) is one of the upstream factors of allergy, which has priming and pro-allergenic effects. In addition, macrophages have also been found to play an important role in the Th2 dominant allergic inflammation by polarizing the M2 phenotype in the pollen-induced experimental allergic conjunctivitis mouse model. Currently, the mechanism of TSLP and M2 macrophages in the pathogenesis of allergic conjunctivitis is not well understood. The role of M2 macrophage polarization in the pathogenesis of allergic conjunctivitis involving TSLP and its downstream molecules was reviewed in this paper.

图2 M2型巨噬细胞参与胸腺基质淋巴细胞生成素-胸腺基质淋巴细胞生成素受体-分化簇134配体途径的示意图
图3 胸腺基质淋巴细胞生成素及其下游分子参与过敏性结膜炎发病可能机制的示意图
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