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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (02) : 65 -69. doi: 10.3877/cma.j.issn.2095-2007.2022.02.001

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原发性玻璃体视网膜淋巴瘤诊断面临的机遇和挑战
贾炜1, 王海燕1,(), 王茹1, 陶勇2, 黄轩2   
  1. 1. 710004 西安市人民医院(西安市第四医院) 陕西省眼科医院眼科
    2. 100020 首都医科大学附属北京朝阳医院眼科
  • 收稿日期:2022-02-05 出版日期:2022-04-28
  • 通信作者: 王海燕
  • 基金资助:
    国家自然科学基金项目(32000485)

Chances and challenges of diagnosing primary vitreoretinal lymphoma

Wei Jia1, Haiyan Wang1,(), Ru Wang1, Yong Tao2, Xuan Huang2   

  1. 1. Department of Ophthalmology, Shaanxi Eye Hospital Xi′an People′s Hospital (Xi′an Fourth Hospital), Xi′an 710004, China
    2. Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  • Received:2022-02-05 Published:2022-04-28
  • Corresponding author: Haiyan Wang
引用本文:

贾炜, 王海燕, 王茹, 陶勇, 黄轩. 原发性玻璃体视网膜淋巴瘤诊断面临的机遇和挑战[J]. 中华眼科医学杂志(电子版), 2022, 12(02): 65-69.

Wei Jia, Haiyan Wang, Ru Wang, Yong Tao, Xuan Huang. Chances and challenges of diagnosing primary vitreoretinal lymphoma[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(02): 65-69.

原发性玻璃体视网膜淋巴瘤(PVRL)患者生存期短,死亡率高,尽早确诊具有生存优势。然而,由于PVRL临床表现多样,影像学检查缺乏特异性,作为"金标准"的病理学诊断率低,廹使临床医师寻找更多的诊断方法。细胞因子、免疫组织化学、分子生物学及分子遗传学分析等检测手段虽然有助于提高诊断率,但仍需要眼科医师提高对PVRL临床表现及影像特征的认知,在合理使用现有检测方法的基础上积极探索更加可靠科学的检查手段。

The patients with primary vitreoretinal lymphoma (PVRL) had a short survival and high mortality, thus urge early diagnosis of this disease was helpful to have the survival superiority. However, due to the variety of clinical manifestations of PVRL, the lack of specificity of imaging examination and the low diagnostic rate of pathology as the gold standard, clinicians were inspirited to find more easy-to-use and valuable methods to assist diagnosis. The detection methods such as cytokines, immunohistochemistry, molecular biology and molecular genetics were of benefit to improve the diagnosis rate, but it was important for ophthalmologists to improve the comprehension of the manifestations and imaging characteristics of PVRL and actively explore more reliable and scientific methods based on the available detection methods.

图5 原发性玻璃体视网膜淋巴瘤患者的光学相干断层扫描图像 图5A示色素上皮层不规则隆起,结节状改变;图5B示玻璃体腔点状强反射,色素上皮呈均匀中弱反射信号连续丘陵状隆起
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