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中华眼科医学杂志(电子版) ›› 2021, Vol. 11 ›› Issue (05) : 316 -320. doi: 10.3877/cma.j.issn.2095-2007.2021.05.012

综述

肿瘤相关性视网膜病变的研究现状
张智辉1, 朱丹2,(), 马建民3   
  1. 1. 010020 呼和浩特,内蒙医科大学第一临床医学院 2019级硕士研究生
    2. 010020 呼和浩特,内蒙古医科大学附属医院眼科
    3. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室
  • 收稿日期:2021-03-19 出版日期:2021-10-28
  • 通信作者: 朱丹
  • 基金资助:
    北京市医院管理中心"登峰"计划专项经费资助(DFL20190201); 北京市自然基金课题(7182038); 国家自然科学基金项目(81860178)

Research status of tumor associated retinopathy

Zhihui Zhang1, Dan Zhu2,(), Janmin Ma3   

  1. 1. Master′s degree 2019, the First Clinical Medical School, Inner Mongolia Medical University, Hohhot 010020, China
    2. Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010020, China
    3. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology&Visual Sciences Key Lab., Beijing 100730, China
  • Received:2021-03-19 Published:2021-10-28
  • Corresponding author: Dan Zhu
引用本文:

张智辉, 朱丹, 马建民. 肿瘤相关性视网膜病变的研究现状[J]. 中华眼科医学杂志(电子版), 2021, 11(05): 316-320.

Zhihui Zhang, Dan Zhu, Janmin Ma. Research status of tumor associated retinopathy[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(05): 316-320.

肿瘤相关性视网膜病变(PR)是副肿瘤综合征(PNS)表现为眼部综合征的一类疾病,而PNS是发生在全身恶性肿瘤背景下的一组异质性疾病。PR通常被分为癌症相关性视网膜病变(CAR)、黑色素瘤相关视网膜病变(MAR)及双眼弥漫性葡萄膜黑色素细胞增生(BDUMP)三类。目前,已知PR是一组具有许多特征的自身免疫性疾病。近年来,尽管有大量研究成果,但在临床实践中无论是此病的诊断还是治疗,都仍然极具挑战性。为帮助临床工作者更好的认识这类疾病,减少漏诊与误诊,更早的发现眼部症状以便于早期诊断和治疗。本文中笔者将从三种肿瘤相关性视网膜病的发病机制、临床特征、诊断及治疗的进展进行综述。

Paraneoplastic retinopathy (PR) is a group of paraneoplastic syndromes (PNS), which had combined with ocular syndrome. Meanwhile, PNS is a heterogeneous disorder under the background of systemic malignant tumor. PR usually has classficated into cancer-associated retinopathy (CAR), melanoma-associated retinopathy (MAR), bilateral diffuse uveal melanocytic proliferation (BDUMP). Currently, it has been demonstrated that PR was a group of autoimmune diseases with many characteristics. In recent years, although extensive research about PR had been done, it is yet a challenge for the diagnosis and treatment for PR in clinical practice. In order to help clinicians better understand PR, reduce missed diagnosis and misdiagnosis, it is important to find earlier ocular symptoms for early diagnosis and treatment. The pathogenesis, clinical features, diagnosis and treatment of 3 kinds of tumor associated retinopathy were reviewed in this paper.

图1 PR患者抗视网膜自身抗体形成原因图
表1 MRA的治疗方法及原理
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