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中华眼科医学杂志(电子版)

中华眼科医学杂志(电子版) ›› 2020, Vol. 10 ›› Issue (05) : 316 -320. doi: 10.3877/cma.j.issn.2095-2007.2020.05.011

综述

血管内皮生长因子对晶状体影响的研究进展
刘泽晗1, 朱丹2,†()   
  1. 1. 010020　呼和浩特，内蒙古医科大学第一临床医学院2018级硕士研究生
    2. 010020　呼和浩特，内蒙古医科大学附属医院眼科
  • 收稿日期:2020-04-27 出版日期:2020-10-28
  • 通信作者: 朱丹
  • 基金资助:
    国家科技重大专项基金项目(2018ZX10101004); 国家自然科学基金项目(81860178)

Recent advances on the effect of vascular endothelial growth factor to human lens

Zehan Liu1, Dan Zhu2,†()   

  1. 1. Master′s degree 2018, the First Clinical Medical School, Inner Mongolia Medical University, Hohhot 010020, China
    2. Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010020, China
  • Received:2020-04-27 Published:2020-10-28
  • Corresponding author: Dan Zhu
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刘泽晗, 朱丹. 血管内皮生长因子对晶状体影响的研究进展[J]. 中华眼科医学杂志(电子版), 2020, 10(05): 316-320.

Zehan Liu, Dan Zhu. Recent advances on the effect of vascular endothelial growth factor to human lens[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020, 10(05): 316-320.

血管内皮生长因子(VEGF)是一种促血管生成因子，在许多病理性血管生成的眼部疾病中起着重要作用。目前，VEGF已成为许多疾病的治疗靶点。然而，现有研究更多关注VEGF在富含血管组织中的作用，忽略了它在非血管组织中的影响。本文中笔者将VEGF-A对晶状体胚胎血管和晶状体大小的影响，以及VEGF-A在年龄相关性白内障、糖尿病性白内障和白内障术后后囊膜混浊等疾病中的作用进行综述，旨在分析VEGF-A对晶状体的影响机制，以期为相关的临床研究提供理论依据。

关键词: 血管内皮生长因子-A, 胚胎血管, 年龄相关性白内障, 糖尿病性白内障, 后囊膜混浊

Vascular endothelial growth factor (VEGF) has been the treatment target of many eye diseases because of its key role in pathological angiogenesis as a pro-angiogenic factor. More attention has been paid to its role in tissues with rich invessels, but not to those lack of vessels. As an important refractive media in the eye, the lens is short of vascular tissues. In this paper, the effect of VEGF-A on embryonic vasculature of human lens, age-related cataract, diabetic cataract and posterior capsule opacification were reviewed so as to analyze the effect of VEGF-A on human lens and its possible mechanism, as well as to provide the oretical basis for relevant clinical studies.

Key words: VEGF-A, Embryonic vasculature, Age-related cataract, Diabetic cataract, Posterior capsule opacification
图1 血管内皮生长因子配体及其对应受体示意图
表1 缺氧环境与缺氧诱导因子-1α对晶状体的作用及机制
第一作者 发表年份 信号通路或作用机制 作用效果
Shui[15] 2008 调控生长调节剂，选择性抑制老年晶状体上皮细胞的增殖和分化过程 诱发年龄相关性白内障的形成
Chen[16] 2008 转录调节器环磷腺苷效应元件结合蛋白2负调节缺氧诱导因子-1信号的表达 促进透明血管系统的形成
Baba[17] 2013 Notch信号通路 调控上皮间充质转化的过程
Goralska[18] 2014 调控铁处理蛋白(如转铁蛋白等)的表达，增加晶状体上皮细胞的铁储存能力 晶状体上皮细胞免于氧化损伤
Chen[19] 2014 热休克蛋白因子-4调控下游缺氧诱导因子-1α的表达 诱发年龄相关性白内障的形成和发展
Han[20] 2015 促进缺氧诱导因子-1α的过表达，阻止细胞凋亡 减缓晶状体混浊的进展，延缓糖尿病性白内障的进展
Cammarata[21] 2015 阻止缺氧诱导因子-1α的表达，下调上皮间充质转化标记蛋白的表达 延缓年龄相关性白内障的发展
Nahomi[22] 2018 转化生长因子β2信号通路 调节上皮间充质转化的过程
图2 内皮细胞中血管内皮生长因子与血管内皮生长因子配体-1-血管内皮生长因子配体-2结合的部分信号通路示意图
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